Heterogeneous III-V/Si micro-ring laser array with multi-state non-volatile memory for ternary content-addressable memories
Not provided.
Science & Technology - Other Topics↗
Engineering topics
Zhang, Chong
Publications and source records attributed to Zhang, Chong.
Phosphoribosylpyrophosphate synthetase as a metabolic valve advances Methylobacterium/Methylorubrum phyllosphere colonization and plant growth
The proficiency of phyllosphere microbiomes in efficiently utilizing plant-provided nutrients is pivotal for their successful colonization of plants. The methylotrophic capabilities of Methylobacterium/Methylorubrum play a crucial role in this process. However, the precise mechanisms facilitating efficient colonization remain elusive. In the present study, we investigate the significance of methanol assimilation in shaping the success of mutualistic relationships between methylotrophs and plants. A set of strains originating from Methylorubrum extorquens AM1 are subjected to evolutionary pressures to thrive under low methanol conditions. A mutation in the phosphoribosylpyrophosphate synthetase gene is identified, which converts it into a metabolic valve. This valve redirects limited C1-carbon resources towards the synthesis of biomass by up-regulating a non-essential phosphoketolase pathway. These newly acquired bacterial traits demonstrate superior colonization capabilities, even at low abundance, leading to increased growth of inoculated plants. This function is prevalent in Methylobacterium/Methylorubrum strains. In summary, our findings offer insights that could guide the selection of Methylobacterium/Methylorubrum strains for advantageous agricultural applications.
59 BASIC BIOLOGICAL SCIENCES↗
High-performance quantum-dot distributed feedback laser on silicon for high-speed modulations
We report a 1310 nm heterogeneous quantum-dot distributed feedback laser on silicon with high efficiency and modulation capability and demonstrate isolator-free external modulation at 25 Gb/s using a metal-oxide semiconductor capacitor microring modulator.
Liang, Di (ORCID:0000000313660115)↗
Ionic self-diffusion of Na[subscript 2]O-Al[subscript 2]O[subscript 3]-SiO[subscript 2] glasses from molecular dynamics simulations
Abstract not provided
Zhao, Yaxian↗
The electrolyte comprising more robust water and superhalides transforms Zn-metal anode reversibly and dendrite-free
A great challenge for all aqueous batteries, including Zn-metal batteries, is the parasitic hydrogen evolution reaction on the low-potential anode. Herein, we report the formula of a highly concentrated aqueous electrolyte that mitigates hydrogen evolution by transforming water molecules more inert. The electrolyte comprises primarily ZnCl 2 and LiCl as an additive, both of which are inexpensive salts. The O–H covalent bonds in water get strengthened in a chemical environment that has fewer hydrogen bonding interactions and a greater number of Zn–Cl superhalides, as suggested by integrated characterization and simulation. As a result, the average Coulombic efficiency of zinc-metal anode is raised to an unprecedented >99.7% at 1 mA cm –2 . In the new electrolyte, the plating/stripping processes leave the zinc-metal anode dendrite-free, and the zinc-metal anode delivers stable plating/stripping cycles for 4000 hours with an areal capacity of 4 mAh cm –2 at 2 mA cm –2 . Furthermore, the high Coulombic efficiency of zinc-metal anode in the ZnCl 2 -LiCl mixture electrolyte is demonstrated in full cells with a limited anode. The V 2 O 5 ·H 2 O| |Zn full cell with an N/P mass ratio of 1.2 delivers a stable life of more than 2500 cycles, and the LiMn 2 O 4 | |Zn hybrid cell with an N/P mass ratio of 0.6 exhibits 1500 cycles in its stable life.
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
Discovery of 3-(thiophen/thiazole-2-ylthio)pyridine derivatives as multitarget anticancer agents
A series of novel 3-(thiophen/thiazole-2-ylthio)pyridine derivatives were designed and synthesized as IGF-1R tyrosine kinase inhibitors. All the target compounds were tested for their IGF-1R kinase inhibitory activities and cytotoxicities against five cancer cell lines (K562, Hep-G2, HCT-116, WSU-DLCL2, and A549). Although all these compounds exhibited moderate to potent cancer cell proliferation inhibitory activities (the most potent compound 43 showed IC{sub 50} value of 1.3 ± 0.9 μM against WSU-DLCL2 cell line), IGF-1R inhibition were not observed. In order to identify the exact target of these analogues, selected compounds were further screened for various kinases. The results indicated that this series of compounds may exert their anticancer activities through inhibiting various kinases including FGFR 3, EGFR, JAK, and RON. In addition, cell cycle analysis of compound 43 on Hep-G2 cells showed cell cycle arrest at G1/G0 phase. All the experiments validated the potential of 3-(thiophen/thiazole-2-ylthio)pyridine analogues as multi-target anticancer agents.
60 APPLIED LIFE SCIENCES↗
Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders
Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory domain, known as UCR2, that opens and closes over the catalytic site for cAMP hydrolysis. The design and optimization of lead compounds was based on iterative analysis of X-ray crystal structures combined with metabolite identification. Selectivity for the activated, dimeric form of PDE4D provided potent memory enhancing effects in a mouse model of novel object recognition with improved tolerability and reduced vascular toxicity over earlier PDE4 inhibitors that lack subtype selectivity. The lead compound, 28 (BPN14770), has entered midstage, human phase 2 clinical trials for the treatment of Fragile X Syndrome.
60 APPLIED LIFE SCIENCES↗
Reverse Dual-Ion Battery via a ZnCl 2 Water-in-Salt Electrolyte
Dual-ion batteries are known for anion storage in the cathode coupled to cation incorporation in the anode. We flip the sequence of the anion/cation-storage chemistries of the anode and the cathode in dual-ion batteries (DIBs) by allowing the anode to take in anions and a cation-deficient cathode to host cations, thus operating as a reverse dual-ion battery (RDIB). The anion-insertion anode is a nano-composite having ferrocene encapsulated inside a micro-porous carbon, and the cathode is a Zn-insertion Prussian blue, Zn-3[Fe(CN)(6)](2). This unique battery configuration benefits from the usage of a 30 m ZnCl2 "water-in-salt" electrolyte. This electrolyte minimizes the dissolution of ferrocene; it raises the cation-insertion potential in the cathode, and it depresses the anion-insertion potential in the anode, thus widening the full cell's voltage by 0.35 V compared with a dilute ZnCl2 electrolyte. RDIBs provide a configuration-based solution to exploit the practicality of cation-deficient cathode materials in aqueous electrolytes.
25 ENERGY STORAGE↗
The anti-tumor effect of regorafenib in lung squamous cell carcinoma in vitro
Highlights: • Regorafenib might be a potential therapeutic medicine for LSCC treatment. • GSK3β activation restricted the anti-tumor activity of regorafenib on LSCC. • GSK3β inhibition could sensitize the anti-proliferation effect of regorafenib. Lung squamous cell carcinoma (LSCC) is a common type of non-small-cell lung cancer (NSCLC) and lacks effective treatment. Regorafenib, an oral multikinase inhibitor, has demonstrated promising anti-tumor activity in various solid tumors. To study whether regorafenib inhibits LSCC cells, we investigate the compound in several LSCC cell lines and explore the possible mechanism. In this study, we confirmed that regorafenib had anti-proliferation effect on LSCC cell lines by inducing G0/G1 arrest. In addition, glycogen synthase kinase 3β (GSK3β) remained at the same level and Ser9 phosphorylation of GSK3β decreased with increasing incubation time and increasing regorafenib concentration in LSCC cells. GSK3β inhibition enhanced the anti-tumor activity of regorafenib. Thus, GSK3β activation restricted the anti-cancer effect of regorafenib on LSCC. In conclusion, regorafenib might be a promising drug for LSCC therapy. GSK3β might be a potential target to increase the anti-tumor effect of regorafenib in LSCC cells.
60 APPLIED LIFE SCIENCES↗
Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice
Abstract not provided
Zhang, Chong↗
Monolithically integrated InAs/InGaAs quantum dot photodetectors on silicon substrates
Not Available
Wan, Yating↗
Deformable complex network for refining low-resolution X-ray structures
A new refinement algorithm called the deformable complex network that combines a novel angular network-based restraint with a deformable elastic network model in the target function has been developed to aid in structural refinement in macromolecular X-ray crystallography. In macromolecular X-ray crystallography, building more accurate atomic models based on lower resolution experimental diffraction data remains a great challenge. Previous studies have used a deformable elastic network (DEN) model to aid in low-resolution structural refinement. In this study, the development of a new refinement algorithm called the deformable complex network (DCN) is reported that combines a novel angular network-based restraint with the DEN model in the target function. Testing of DCN on a wide range of low-resolution structures demonstrated that it constantly leads to significantly improved structural models as judged by multiple refinement criteria, thus representing a new effective refinement tool for low-resolution structural determination.
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗