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Zhang, Jianguo

Publications and source records attributed to Zhang, Jianguo.

A roadmap for China to peak carbon dioxide emissions and achieve a 20% share of non-fossil fuels in primary energy by 2030

As part of its Paris Agreement commitment, China pledged to peak carbon dioxide (CO 2 ) emissions around 2030, striving to peak earlier, and to increase the non-fossil share of primary energy to 20% by 2030. Yet by the end of 2017, China emitted 28% of the world's energy-related CO 2 emissions, 76% of which were from coal use. How China can reinvent its energy economy cost-effectively while still achieving its commitments was the focus of a three-year joint research project completed in September 2016. Overall, this analysis found that if China follows a pathway in which it aggressively adopts all cost-effective energy efficiency and CO 2 emission reduction technologies while also aggressively moving away from fossil fuels to renewable and other non-fossil resources, it is possible to not only meet its Paris Agreement Nationally Determined Contribution (NDC) commitments, but also to reduce its 2050 CO 2 emissions to a level that is 42% below the country's 2010 CO 2 emissions. While numerous barriers exist that will need to be addressed through effective policies and programs in order to realize these potential energy use and emissions reductions, there are also significant local environmental (e.g., air quality), national and global environmental (e.g., mitigation of climate change), human health, and other unquantified benefits that will be realized if this pathway is pursued in China.

54 ENVIRONMENTAL SCIENCES↗

miR-1236-3p suppresses the migration and invasion by targeting KLF8 in lung adenocarcinoma A549 cells

MicroRNAs (miRNAs) have a great effect on regulating tumor cell migration, invasion, proliferation and prognosis. However, the mechanism of miR-1236-3p on regulating carcinogenesis is still unknown. In this study, the expression of miR-1236-3p was lower in lung adenocarcinoma tissues than that in adjacent normal tissue. In lung adenocarcinoma A549 cell line, miR-1236-3p decreased ability of cell invasion and migration, furthermore, we show that KLF8 is targeted by miR-1236-3p, and expression of miR-1236-3p is negatively correlated with KLF8. Additionally, miR-1236-3p suppressed the expression of KLF8 and EMT (epithelial mesenchymal transition)-related genes. Overexpression of KLF8 can promote EMT-related genes at protein level. In conclusion, our results support the fact that miR-1236-3p acts as a tumor inhibitor in lung adenocarcinoma by suppressing the activity of KLF8, and it may play a critical role in the diagnosis and treatment of lung cancer.

60 APPLIED LIFE SCIENCES↗

Evolutionary transients in the rice transcriptome.

The number of protein-coding genes predicted from the rice genome remains much larger than the number of genes for Arabidopsis. Most of the excess rice genes show low similarity to Arabidopsis, and eudicots in general. It is difficult to repudiate these genes because even for the 19,079 non-redundant rice cDNAs that have been sequenced, 34.3% are low similarity. Here, we describe a major contributor to this excess of low similarity genes: the frequent and continued occurrence of gene duplications in plants, and the post- duplicative degradation (i.e. relaxed selection) that is typically expected to occur in one of the two gene copies. The salient feature of this degradation is an increase in Ka/Ks for Ks per available site, respectively. We show that low similarity genes are expressed at lower mRNA and protein levels than other genes, and that regions of the encoded proteins are structurally disordered. Indeed, many are evolutionary “transients” that may be destined to die, even if they remain transcriptionally active for millions of years.

59 BASIC BIOLOGICAL SCIENCES↗