NASA NTRS · 19790053926
Chemical evolution. XXIX - Pyrimidines from hydrogen cyanide
Abstract
Compounds obtained by hydrolysis of HCN oligomers formed by allowing pH 9.2, 0.1 M cyanide to stand at room temperature for 4 to 12 months were analyzed. Hydrolysis of HCN oligomers yielded 4,5-dihydroxypyrimidine and 5-hydroxyuracil; orotic acid was detected after hydrolysis at pH 8.5. A unified pathway from diaminofumaronitrile to the pyrimidines observed is suggested. As purines, pyrimidines and amino acids are released by hydrolysis of HCN oligomers in either acidic or mildly basic aqueous solutions, they could have been formed on the primitive earth in spite of fluctuations in pH. 4,5-dihydroxypyrimidines appear to be likely candidates for incorporation into primitive nucleic acids, as they should undergo Watson-Crick hydrogen bonding with adenine.
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Ferris, J. P., Joshi, P. C., Lawless, J. G.. 1978-01-01. Chemical evolution. XXIX - Pyrimidines from hydrogen cyanide. https://ntrs.nasa.gov/citations/19790053926
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