Implications of otoconial changes in microgravity

Abstract

Otoconia of maculas of Sprague-Dawley rats (Taconic Farms) flown aboard Spacelab-3 showed no signs of demineralization. Other findings were accumulations of miniature otoconia at the lateral border of utricular patches and a smoothing of surfaces of saccular otoconia. These features were not observed in age- and weight-matched ground controls. Subsequent study showed otoconial asymmetry to be normal in this strain. Further research in space, taking this into account, is clearly required. Findings of ground-based studies would suggest that neural structures of maculas are adaptable to microgravity but might show changes over time. Moreover, maculas have the potential for integration of the sort ascribed to brain and retina, although on a less complex scale. They may act as comparators, and asymmetry may be an important property. Coordinated studies in space and on the ground could lead to new understanding of how maculas function and adapt to new acceleratory environments; and to insights about the functioning of neural tissue in general.