NASA NTRS · 19920068875
Spaceflight alters immune cell function and distribution
Abstract
Experiments are described which were performed onboard Cosmos 2044 to determine spaceflight effects on immunologically important cell function and distribution. Results indicate that bone marrow cells from flown and suspended rats exhibited a decreased response to a granulocyte/monocyte colony-stimulating factor compared with the bone marrow cells from control rats. Bone marrow cells showed an increase in the percentage of cells expressing markers for helper T-cells in the myelogenous population and increased percentages of anti-asialo granulocyte/monocyte-1-bearing interleulin-2 receptor bearing pan T- and helper T-cells in the lymphocytic population.
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Sonnenfeld, Gerald, Mandel, Adrian D., Konstantinova, Irina V., Berry, Wallace D., Taylor, Gerald R., Lesniak, A. T., Fuchs, Boris B., Rakhmilevich, Alexander L.. 1992-08-01. Spaceflight alters immune cell function and distribution. https://ntrs.nasa.gov/citations/19920068875
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