NASA NTRS · 20030068012
Pentopyranosyl Oligonucleotide Systems
Abstract
To determine whether the remarkable chemical properties of the pyranosyl isomer of RNA as an informational Watson-Crick base-pairing system are unique to the pentopyranosyl-(4 + 2)-oligonucleotide isomer derived from the RNA-building block D-ribose, studies on the entire family of diastereoisomeric pyranosyL(4 - Z)-oligonucleotide systems deriving from D-ribose. L-lyxose. D-xylose, and L-arabinose were carried out. The result of these extended studies is unambiguous: not only pyranosyl-RNA, but all members of the pentopyranosyl(4 + 2)-oligonucleotide family are highly efficient Watson-Crick base-pairing systems. Their synthesis and pairing properties will be described in a series of publications in this journal.
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Reck, Folkert, Kudick, Rene, Krishnamurthy, Ramanarayanan, Eschenmoser, Albert, Wippo, Harald. 2001-01-01. Pentopyranosyl Oligonucleotide Systems. https://ntrs.nasa.gov/citations/20030068012
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