New optical scheme for a polarimetric-based glucose sensor

Ansari, Rafat R.; Bockle, Stefan; Rovati, Luigi

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NASA NTRS · 20040087418

New optical scheme for a polarimetric-based glucose sensor

Ansari, Rafat R.·Bockle, Stefan·Rovati, Luigi

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Abstract

A new optical scheme to detect glucose concentration in the aqueous humor of the eye is presented. The ultimate aim is to apply this technique in designing a new instrument for, routinely and frequently, noninvasively monitoring blood glucose levels in diabetic patients without contact (no index matching) between the eye and the instrument. The optical scheme exploits the Brewster reflection of circularly polarized light off of the lens of the eye. Theoretically, this reflected linearly polarized light on its way to the detector is expected to rotate its state of polarization, owing to the presence of glucose molecules in the aqueous humor of a patient's eye. An experimental laboratory setup based on this scheme was designed and tested by measuring a range of known concentrations of glucose solutions dissolved in water. (c) 2004 Society of Photo-Optical Instrumentation Engineers.

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Evaluation Studies Validation Studies Optics/instrumentation Diabetes Mellitus/blood/metabolism Models, Biological Glucose/analysis Refractometry/instrumentation/methods Aqueous Humor/chemistry Blood Glucose/analysis Comparative Study Computer Simulation Human Equipment Design Support, Non-U.S. Gov't Equipment Failure Analysis Refraction, Ocular Support, U.S. Gov't, Non-P.H.S Microscopy, Polarization/instrumentation/methods

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Ansari, Rafat R., Bockle, Stefan, Rovati, Luigi. 2004-01-01. New optical scheme for a polarimetric-based glucose sensor. https://ntrs.nasa.gov/citations/20040087418

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