Progress toward an explicit mechanistic model for the light-driven pump, bacteriorhodopsin

Lanyi, J. K.

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NASA NTRS · 20040141720

Progress toward an explicit mechanistic model for the light-driven pump, bacteriorhodopsin

Lanyi, J. K.

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Abstract

Recent crystallographic information about the structure of bacteriorhodopsin and some of its photointermediates, together with a large amount of spectroscopic and mutational data, suggest a mechanistic model for how this protein couples light energy to the translocation of protons across the membrane. Now nearing completion, this detailed molecular model will describe the nature of the steric and electrostatic conflicts at the photoisomerized retinal, as well as the means by which it induces proton transfers in the two half-channels leading to the two membrane surfaces, thereby causing unidirectional, uphill transport.

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Review, Tutorial Review Non-NASA Center NASA Discipline Exobiology Bacteriorhodopsins/chemistry/metabolism Biological Transport Protein Conformation Photochemistry Models, Chemical

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Lanyi, J. K.. 1999-12-31. Progress toward an explicit mechanistic model for the light-driven pump, bacteriorhodopsin. https://ntrs.nasa.gov/citations/20040141720

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