Determining blood and plasma volumes using bioelectrical response spectroscopy

Siconolfi, S. F.; Nusynowitz, M. L.; Suire, S. S.; Moore, A. D. Jr; Leig, J.

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NASA NTRS · 20040173093

Determining blood and plasma volumes using bioelectrical response spectroscopy

Siconolfi, S. F.·Nusynowitz, M. L.·Suire, S. S.·Moore, A. D. Jr·Leig, J.

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Abstract

We hypothesized that an electric field (inductance) produced by charged blood components passing through the many branches of arteries and veins could assess total blood volume (TBV) or plasma volume (PV). Individual (N = 29) electrical circuits (inductors, two resistors, and a capacitor) were determined from bioelectrical response spectroscopy (BERS) using a Hewlett Packard 4284A Precision LCR Meter. Inductance, capacitance, and resistance from the circuits of 19 subjects modeled TBV (sum of PV and computed red cell volume) and PV (based on 125I-albumin). Each model (N = 10, cross validation group) had good validity based on 1) mean differences (-2.3 to 1.5%) between the methods that were not significant and less than the propagated errors (+/- 5.2% for TBV and PV), 2) high correlations (r > 0.92) with low SEE (< 7.7%) between dilution and BERS assessments, and 3) Bland-Altman pairwise comparisons that indicated "clinical equivalency" between the methods. Given the limitation of this study (10 validity subjects), we concluded that BERS models accurately assessed TBV and PV. Further evaluations of the models' validities are needed before they are used in clinical or research settings.

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NASA Discipline Number 00-00 NASA Program Flight NASA Center JSC NASA Discipline Cardiopulmonary Plasma Volume Blood Volume Regression Analysis Electric Conductivity Reproducibility of Results Male Evaluation Studies Female Human Adult Electric Impedance

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Siconolfi, S. F., Nusynowitz, M. L., Suire, S. S., Moore, A. D. Jr, Leig, J.. 1996-12-01. Determining blood and plasma volumes using bioelectrical response spectroscopy. https://ntrs.nasa.gov/citations/20040173093

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