NASA NTRS · 20080006007
Nucleozymes
Abstract
Nucleozymes containing ribonucleotides and deoxyribonucleotides or nucleic acid analogues are described herein. The nucleozymes have catalytic activity and are significantly more resistant to degradation than their all-RNA ribozyme counterparts. Also described are methods for preparing the nucleozymes along with methods of using nucleozymes, e.g., as therapeutic agents.
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Usman, Nassim, Cedergren, Robert J., Perreault, Jean-Pierre, Yang, Jing-Hua, Rich, Alexander. 2004-03-30. Nucleozymes. https://ntrs.nasa.gov/citations/20080006007
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