NASA NTRS · 20210014767
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Heather Hare, Cheol Parl, Sang-hyon Chu. Optimizing Multilayer Shielding Designs Using OLTARIS. https://ntrs.nasa.gov/citations/20210014767
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The Space Radiation Element (SRE) with the Human Research Program (HRP) and NASA is tasked with the mission of characterizing and facilitating the management of the human health outcomes associated with space radiation exposure to ultimately protect astronaut health as well as enable human space exploration. To facilitate our mission, we provide funding for space radiation research but also provide several unique opportunities discussed below to educate and disseminate space radiation knowledge.
Space radiation poses an increased risk for cardiovascular diseases (CVD) during and after spaceflight, that should be quantified to plan future space missions such as the flight to Mars. The radiation-induced CVD risk is evaluated using a linear no-threshold dose response excess relative risk (ERR) model, so that the risk is function of the radiation dose and of the background (i.e., non-exposed) incidence rate. The background CVD risk can be evaluated using clinical prediction models (CPMs). The first CPMs developed in the 1960’s have identified CVD risk factors such as blood pressure, diabetes, cholesterol, and smoking. In this work, the steps used to integrate the CVD risk provided by a CPM into the NASA Radiation Risk Model are described. Simulation results calculated using available data for relevant mission scenarios are also shown, and the challenges in CVD risk predictions are discussed.