NASA NTRS · 20230005879
Develop a deep space tool with autonomous life support technologies to study the biological effects of the space radiation environment.
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Matthew Napoli, Andres Dono Perez, Jose Luis Alvarellos. BioSentinel. https://ntrs.nasa.gov/citations/20230005879
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BioSentinel was one of ten CubeSats launched by the Space Launch System (SLS) as part of the Artemis I campaign on 16 November 2022. A lunar flyby gave BioSentinel the needed energy to escape the Earth-Moon system into heliocentric space. The biological payload contains yeast cells designed to measure radiation in deep space beyond the reach of Earth’s magnetosphere. This paper discusses in detail the BioSentinel flight performance, as well as challenges and lessons learned prior to, and during the mission.
BioSentinel will conduct the first study of the biological response to space radiation outside LEO since the Apollo missions. The project will investigate the biological effects of space radiation, and will provide an adaptable platform to perform human relevant measurements in multiple space environments in the future, including on lunar and Mars landers and orbiters.
Each payload has 18 fluidic cards and each fluidic card has 16 microfluidic wells, for a total of 288 wells. Card activation occurs at different time points throughout the 6-month mission and following ground commands. At each timepoint, two fluidic cards are filled with growth medium containing nutrients and a metabolic indicator dye. In addition to card filling, the temperature of the cards increases from ~4°C (stasis mode) to 23°C to allow for cell growth. The metabolic dye changes color from blue to pink, then pink to clearin the presence of metabolically active yeast cells. The colorimetric changes and cell growth are monitored using a 3-light-emitting diode(LED)optical detection system. The optical data determines how fast the cells are able to recover after accumulating radiation damage over time.After ground command initiation, all the fluidics, thermal and optical detection steps in BioSentinel are fully automated.The biosensor response data is compared to physical dosimetry data collected onboard the same payload. This dosimeter or linear energy transfer (LET)spectrometer is based on TimePix chip technology. This chip measures the total ionizing radiation dose in addition to calculating the LET of each particle that traverses its sensor, thus allowing researchers to characterize the radiation environment around the payload.The biological response (and physical dosimetry) on ISS over time is compared to the deep space mission and to data obtained on the ground.This analysis provides insight on the biological effects of the space radiation exposure in preparation for future long-duration missions to space and inhabitation beyond low-Earth orbit (LEO).