NASA NTRS · 20250000914
Somatic Mutation Analysis in Spaceflight: NASA Twins Genome Study
Abstract
The NASA Twins Genome Study investigates the effects of spaceflight on somatic mutation accumulation by comparing genome-wide sequence data from a spaceflight astronaut and his Earth-bound twin. Utilizing advanced computational software on high performance computers, this study identifies and maps somatic mutations, with implications for understanding spaceflight-associated health risks, including cancer, neurodegeneration, and cardiovascular disease. The findings aim to bridge rodent and human space research, offering insights into tissue-specific pathophysiology, risk models, and potential therapeutic interventions.
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Viktor Stolc, Miloslav Karhanek, David J Loftus. Somatic Mutation Analysis in Spaceflight: NASA Twins Genome Study. https://ntrs.nasa.gov/citations/20250000914
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