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DOE OSTI · 1134715

Methods for threshold determination in multiplexed assays

Tammero, Lance F. Bentley·Dzenitis, John M·Hindson, Benjamin J
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Abstract

Methods for determination of threshold values of signatures comprised in an assay are described. Each signature enables detection of a target. The methods determine a probability density function of negative samples and a corresponding false positive rate curve. A false positive criterion is established and a threshold for that signature is determined as a point at which the false positive rate curve intersects the false positive criterion. A method for quantitative analysis and interpretation of assay results together with a method for determination of a desired limit of detection of a signature in an assay are also described.

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BibTeXRIS

Tammero, Lance F. Bentley, Dzenitis, John M, Hindson, Benjamin J. 2014-06-24. Methods for threshold determination in multiplexed assays. https://www.osti.gov/biblio/1134715

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