Dielectrokinetic chromatography devices

Chirica, Gabriela S; Fiechtner, Gregory J; Singh, Anup K

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DOE OSTI · 1165448

Dielectrokinetic chromatography devices

Chirica, Gabriela S·Fiechtner, Gregory J·Singh, Anup K

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Abstract

Disclosed herein are methods and devices for dielectrokinetic chromatography. As disclosed, the devices comprise microchannels having at least one perturber which produces a non-uniformity in a field spanning the width of the microchannel. The interaction of the field non-uniformity with a perturber produces a secondary flow which competes with a primary flow. By decreasing the size of the perturber the secondary flow becomes significant for particles/analytes in the nanometer-size range. Depending on the nature of a particle/analyte present in the fluid and its interaction with the primary flow and the secondary flow, the analyte may be retained or redirected. The composition of the primary flow can be varied to affect the magnitude of primary and/or secondary flows on the particles/analytes and thereby separate and concentrate it from other particles/analytes.

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY 59 BASIC BIOLOGICAL SCIENCES 60 APPLIED LIFE SCIENCES

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Chirica, Gabriela S, Fiechtner, Gregory J, Singh, Anup K. 2014-12-16. Dielectrokinetic chromatography devices. https://www.osti.gov/biblio/1165448

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