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DOE OSTI · 1190922

Peptides whose uptake by cells is controllable

Jiang, Tao·Olson, Emilia S.·Whitney, Michael·Tsien, Roger
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Abstract

A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.

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BibTeXRIS

Jiang, Tao, Olson, Emilia S., Whitney, Michael, Tsien, Roger. 2015-07-07. Peptides whose uptake by cells is controllable. https://www.osti.gov/biblio/1190922

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