DOE OSTI · 1193384
Cellulase variants
Abstract
This invention provides novel variant cellulolytic enzymes having improved activity and/or stability. In certain embodiments the variant cellulotyic enzymes comprise a glycoside hydrolase with or comprising a substitution at one or more positions corresponding to one or more of residues F64, A226, and/or E246 in Thermobifida fusca Cel9A enzyme. In certain embodiments the glycoside hydrolase is a variant of a family 9 glycoside hydrolase. In certain embodiments the glycoside hydrolase is a variant of a theme B family 9 glycoside hydrolase.
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Blazej, Robert, Toriello, Nicholas, Emrich, Charles, Cohen, Richard N., Koppel, Nitzan. 2015-07-14. Cellulase variants. https://www.osti.gov/biblio/1193384
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