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DOE OSTI · 1531919

Methods for determining absorbed dose information

Sgouros, George·Song, Hong·Prideaux, Andrew·Hobbs, Robert
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Abstract

The disclosure discusses methods for determining absorbed dose information. A tomography imaging device generates an anatomy image relating to anatomy of a particular patient. A tomography imaging device also generates multiple radioactivity images regarding radioactivity distribution of an internally administered pharmaceutical over time in the particular patient. The radioactivity images related to the radioactivity distribution over time are registered. Each radioactivity image is combined with each anatomy image to create activity images. A Monte Carlo simulation for each activity image is run to obtain absorbed dose-rate images of the pharmaceutical at multiple times. The absorbed dose-rate images are integrated over time to obtain a total absorbed dose image. The absorbed dose-rate images and the total absorbed dose image are used to obtain a biologically effective dose (BED) image. The BED image is used to obtain an equivalent uniform does (EUD) of BED values for a chosen anatomical region.

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62 RADIOLOGY AND NUCLEAR MEDICINE

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BibTeXRIS

Sgouros, George, Song, Hong, Prideaux, Andrew, Hobbs, Robert. 2016-07-12. Methods for determining absorbed dose information. https://www.osti.gov/biblio/1531919

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