Positive modulator of bone morphogenic protein-2

Zamora, Paul O.; Pena, Louis A.; Lin, Xinhua; Takahashi, Kazuyuki

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DOE OSTI · 1650734

Positive modulator of bone morphogenic protein-2

Zamora, Paul O.·Pena, Louis A.·Lin, Xinhua·Takahashi, Kazuyuki

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Abstract

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY 59 BASIC BIOLOGICAL SCIENCES

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Zamora, Paul O., Pena, Louis A., Lin, Xinhua, Takahashi, Kazuyuki. 2020-04-07. Positive modulator of bone morphogenic protein-2. https://www.osti.gov/biblio/1650734

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