Detecting compounds in microfluidic droplets using mass spectrometry

Northen, Trent Russell; Heinemann, Joshua Vance

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DOE OSTI · 1650974

Detecting compounds in microfluidic droplets using mass spectrometry

Northen, Trent Russell·Heinemann, Joshua Vance

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Abstract

Disclosed herein are devices and methods for detecting compounds in droplets using mass spectrometry. In some embodiments, the device comprises: a microfluidics-MS (microMS) device, wherein the microMS device comprises: a droplet-to-digital microfluidic device, wherein the droplet-to-digital microfluidic device comprises: a glass layer; an electrode layer comprising chrome electrodes etched onto one side of the glass layer; a dielectric layer configured for electrowetting; and a microfluidics layer comprising channels, pockets, and a droplet generator, for example a T-junction droplet generator, wherein the pockets are connected to the channels; and a mass spectrometry plate, wherein the mass spectrometry plate is reversibly sealed to the microfluidic device.

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY 59 BASIC BIOLOGICAL SCIENCES

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Northen, Trent Russell, Heinemann, Joshua Vance. 2020-06-02. Detecting compounds in microfluidic droplets using mass spectrometry. https://www.osti.gov/biblio/1650974

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