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DOE OSTI · 1651020

Methods related to a structure of high-affinity human PD-1/PD-L2 complex

Tang, Shaogeng·Kim, Peter S.
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Abstract

Variants of human PD-1 comprising one or more of amino acid substitutions in residues corresponding to N74, T76 and A132 of SEQ ID NO:1 are described. Also described are structures, obtained using X-ray crystallography, of the human PD-1/PD-L2 complex and mutant PD-1 variants. The structures of human PD-1 described in the present disclosure are useful in drug discovery, including small-molecule drug discovery. Accordingly, methods of using the structures in drug discovery are also described.

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BibTeXRIS

Tang, Shaogeng, Kim, Peter S.. 2020-06-16. Methods related to a structure of high-affinity human PD-1/PD-L2 complex. https://www.osti.gov/biblio/1651020

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