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DOE OSTI · 1661908

Omics-Lethal Human Viruses, Ebola Experiment EHUVEC001

Anderson, Lindsey N.·Eisfeld, Amie J.·Waters, Katrina M.
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Abstract

The purpose of this experiment was to evaluate the human host response to Zaire Ebola wild-type virus and mutant virus infection in VP30 expression background. Samples were obtained from human umbilical cord endothelial cells (HUVEC) infected with wild-type Zaire Ebola virus in the ΔVP30 background (deltaVP30-WT) and mutant lacking the mucin domain (deltaVP30-deltamucin) encoding a glycoprotein lacking the mucin domain for mRNA transcriptome expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset downloads have a direct relationship to a primary sample submission corresponding to a specific Ebola virus infection.

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59 BASIC BIOLOGICAL SCIENCESBioProject Accession Number [NCIT:C175890]Data Download [schema:DataDownload]data transformation [SIO:000594]differential expression analysis [SWO:7000018]Ebola virus [NCBITAXON:186536]Gene expression profile data [edam.data:0928]Human virus [NCIT:C14317]Immune Response [GO:0006955]Omics [edam.topic:3391]Time Sampled Measurement Datasets [IAO:0000584]Virology [edam.topic:0781]

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Anderson, Lindsey N., Eisfeld, Amie J., Waters, Katrina M.. 2021-01-18. Omics-Lethal Human Viruses, Ebola Experiment EHUVEC001. https://doi.org/10.25584/lhvehuvec001%2F1661908

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