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DOE OSTI · 1661954

Omics-Lethal Human Viruses, West Nile Experiment WCT001

Anderson, Lindsey N.·Eisfeld, Amie J.·Waters, Katrina M.
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Abstract

The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNV-NY99 382) and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt) virus infection. Sample data was obtained from mouse cortex tissue for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Tissues from this experiment were matched to tissues from GSE77192 (WCB001), using 1/4 of the cortex and 1/2 of cerebellum from the same mice. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific West Nile virus infection.

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59 BASIC BIOLOGICAL SCIENCESBioProject Accession Number [NCIT:C175890]Data Download [schema:DataDownload]data transformation [SIO:000594]differential expression analysis [SWO:7000018]Gene expression profile data [edam.data:0928]Immune Response [GO:0006955]Mass spectrometry data [edam.data:2536]MassIVE dataset identifier [MS:1002487]Multi-omics [edam.topic:4021]Mus musculus [NCBITAXON:10090]Omics [edam.topic:3391]Time Sampled Measurement Datasets [IAO:0000584]Virology [edam.topic:0781]West Nile Virus [NCBITAXON:11082]

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Anderson, Lindsey N., Eisfeld, Amie J., Waters, Katrina M.. 2021-01-18. Omics-Lethal Human Viruses, West Nile Experiment WCT001. https://doi.org/10.25584/lhvwct001%2F1661954

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