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DOE OSTI · 1663165

The D614G mutation in Spike: increased infectivity and neutralizing Ab sensitivity and the underlying mechanism [Slides]

Korber, Bette Tina Marie
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Abstract

Evidence is presented that there are now more SARS-CoV-2 viruses circulating in the human population globally that have the G614 form that was originally identified from the first human cases in Wuhan, China. Follow-up studies show that patients infected with G614 shed more viral nucleic avid compared with those with D614 and G614-bearing viruses show significantly higher infectious titers in vitro than their D614 counterparts.

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59 BASIC BIOLOGICAL SCIENCESCovid-19SARS-CoV-2

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Korber, Bette Tina Marie. 2020-09-18. The D614G mutation in Spike: increased infectivity and neutralizing Ab sensitivity and the underlying mechanism [Slides]. https://doi.org/10.2172/1663165

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