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DOE OSTI · 1784370

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

Yuan, Meng·Huang, Deli·Lee, Chang-Chun D.·Wu, Nicholas C.·Jackson, Abigail M.·Zhu, Xueyong·Liu, Hejun·Peng, Linghang·van Gils, Marit J.·Sanders, Rogier W.·Burton, Dennis R.·Reincke, S. Momsen·Prüss, Harald·Kreye, Jakob·Nemazee, David·Ward, Andrew B.·Wilson, Ian A.
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Abstract

Defenses against SARS-CoV-2 variants Our key defense against the COVID-19 pandemic is neutralizing antibodies against the SARS-CoV-2 virus elicited by natural infection or vaccination. Recent emerging viral variants have raised concern because of their potential to escape antibody neutralization. Wang et al . identified four antibodies from early-outbreak convalescent donors that are potent against 23 variants, including variants of concern, and characterized their binding to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Yuan et al . examined the impact of emerging mutations in the receptor-binding domain of the spike protein on binding to the host receptor ACE2 and to a range of antibodies. These studies may be helpful for developing more broadly effective vaccines and therapeutic antibodies. —VV

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Yuan, Meng, Huang, Deli, Lee, Chang-Chun D., Wu, Nicholas C., Jackson, Abigail M., Zhu, Xueyong, Liu, Hejun, Peng, Linghang, van Gils, Marit J., Sanders, Rogier W., Burton, Dennis R., Reincke, S. Momsen, Prüss, Harald, Kreye, Jakob, Nemazee, David, Ward, Andrew B., Wilson, Ian A.. 2021-08-13. Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants. https://doi.org/10.1126/science.abh1139

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