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DOE OSTI · 1786979

PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Interferon-Stimulated Response to Virus Infection, Processed Experimental Dataset Catalog

Anderson, Lindsey N.·Eisfeld, Amie J.·Waters, Katrina M.
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Abstract

Human Interferon (IFN) alpha, beta, and gamma participate in the body's natural immune response to lethal virus infection and disease.The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013 - 2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics (T) dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific Human Interferon (IFN), interferon alpha (IFNα), interferon beta (IFNβ), and/or interferon gamma (IFNγ) stimulated response to an experimental virus infection treatment study. Host sample types include cerebellum ["CB", BTO:0000232], cortical neurons ["CN", BTO:0004102], cortex ["CT", BTO:0000233], dendritic cells ["DC", BTO:0002042], granule cell neurons ["GCN", BTO:0003393], lymph node ["LN", BTO:0000784], and serum ["SE", BTO:0001239] from mouse (Mus musculus) tissue collections.

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59 BASIC BIOLOGICAL SCIENCESBioProject Accession Number [NCIT:C175890]data transformation [SIO:000594]Dataset Collection [schema:DataCatalog]differential expression analysis [SWO:7000018]Gene expression profile data [edam.data:0928]Human Interferon [NCIT:C20493]Immune Response [GO:0006955]Interferon Alpha [NCIT:C20494]Interferon Beta [NCIT:C20495]Interferon Gamma [NCIT:C20496]Mass spectrometry data [edam.data:2536]MassIVE dataset identifier [MS:1002487]Multi-omics [edam.topic:4021]Omics [edam.topic:3391]Time Sampled Measurement Datasets [IAO:0000584]Virology [edam.topic:0781]

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Anderson, Lindsey N., Eisfeld, Amie J., Waters, Katrina M.. 2021-01-18. PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Interferon-Stimulated Response to Virus Infection, Processed Experimental Dataset Catalog. https://doi.org/10.25584/lhvifn%2F1786979

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