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DOE OSTI · 1874024

Structural analyses of macromolecules by solution scattering (CRADA Final Report)

Hammel, Michal
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Abstract

New innovative Small Angle X-ray Scattering (SAXS) methods to visualized macromolecules in solution at low resolution has led the SIBYLS group at Lawrence Berkeley Lab in being a world leader in biological SAXS. This research is particularly important now as LBNL establishes high-priority research topics including molecular to mesoscale analysis. This new expanding area of research relies on and ties in with our efforts towards developing a solution structure modeling tool for RNA structure prediction. Due to the pandemic our efforts focused on the SARS-CoV-2 proteins and RNA interactions. Specifically, we characterized SARS-CoC-2 proteins interaction with RNA (Wilanowski et al. 2021 -Hammel group) and Nucleoprotein interaction with RNA (Schneidman group).

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Hammel, Michal. 2021-10-01. Structural analyses of macromolecules by solution scattering (CRADA Final Report). https://doi.org/10.2172/1874024

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