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DOE OSTI · 1908128

Programmed Supramolecular Assemblies Using Orthogonal Pairs of Heterodimeric Coiled Coil Peptides

Jiang, Linhai·Zuo, Xiaobing·Li, Jianping·Traaseth, Nathaniel J.·Kirshenbaum, Kent
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Abstract

Despite recent progress, it remains challenging to program biomacromolecules to assemble into discrete nanostructures with pre-determined sizes and topologies. We report here a novel strategy to address this challenge. By using two orthogonal pairs of heterodimeric coiled coils as the building blocks, we constructed six discrete supramolecular assemblies, each composed of a prescribed number of coiled coil components. Within these assemblies, different coiled coils were connected via end-to-side covalent linkages strategically pre-installed between the non-complementary pairs. The overall topological features of two highly complex assemblies, a “barbell” and a “quadrilateral” form, were characterized experimentally and were in good agreement to the designs. This work expands the design paradigms for peptide-based discrete supramolecular assemblies and will provide a route for de novo fabrication of functional protein materials.

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Jiang, Linhai, Zuo, Xiaobing, Li, Jianping, Traaseth, Nathaniel J., Kirshenbaum, Kent. 2022-04-12. Programmed Supramolecular Assemblies Using Orthogonal Pairs of Heterodimeric Coiled Coil Peptides. https://doi.org/10.1002/anie.202201895

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