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DOE OSTI · 1971764

PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection

Anderson, Lindsey N.·Eisfeld, Amie J.·Waters, Katrina M.
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Abstract

The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host Responses to Understand Severe Human Virus Infections" program project was a highly integrated and comprehensive systems biology research core, funded by the National Institute of Health (U19AI106772) from 2013-06-01 to 2018-05-31, investigating the complex host response to category A, B, and C priority pathogen infections. Resulting project deliverables include an extensive comprehensive collections of linked primary and secondary transformation viral experimental infection data. Here we provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open access to viral Omics lifecycle datasets and project metadata. Using a highly integrated and multidisciplinary approach, linked primary data and metadata supporting secondary normalization datasets, provide critical information necessary for research reproducibility and long-term preservation. Enabling on-demand data access for research community consumption and developer reuse, serves to support new mechanistic insights and discoveries into host-pathogen interactions for aiding future biohazard data preparedness efforts in emergency response to global health crises involving viral infection.

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59 BASIC BIOLOGICAL SCIENCESBioProject Accession Number [NCIT:C175890]data transformation [SIO:000594]Dataset Collection [schema:DataCatalog]differential expression analysis [SWO:7000018]Ebolavirus [NCBITAXON:186536]Gene expression profile data [edam.data:0928]Human Interferon [NCIT:C20493]Human virus [NCIT:C14317]Immune Response [GO:0006955]Influenza A virus [NCBITAXON:11320]Mass spectrometry data [edam.data:2536]MassIVE dataset identifier [MS:1002487]MERS-CoV [NCBITAXON:1335626]Multi-omics [edam.topic:4021]Omics [edam.topic:3391]Time Sampled Measurement Datasets [IAO:0000584]Virology [edam.topic:0781]West Nile virus [NCBITAXON:11082]

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Anderson, Lindsey N., Eisfeld, Amie J., Waters, Katrina M.. 2023-01-30. PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection. https://doi.org/10.25584/prj.u19ai106772%2F1971764

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