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DOE OSTI · 1993127

Topology Data Analysis Guided Prompt Optimization of Segment Anything Model for Zero-Shot Segmentation of Biological Images

Glatt, R·Shusen, L
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Glatt, R, Shusen, L. 2023-05-15. Topology Data Analysis Guided Prompt Optimization of Segment Anything Model for Zero-Shot Segmentation of Biological Images. https://www.osti.gov/biblio/1993127

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DOE OSTI2022

Model Choice Metrics to Optimize Profile-QSAR Performance

Predicting molecular activity against protein targets is difficult because of the paucity of experimental data. Approaches like multitask modeling and collaborative filtering seek to improve model accuracy by leveraging results from multiple targets, but are limited because different compounds are measured with different assays, leading to sparse data matrices. Profile-QSAR (pQSAR) 2.0 addresses this problem by fitting a series of partial least squares models for each target, using as features the predictions from single-task models on the remaining targets. Here, this method has been shown to produce better results than single task and multitask models. However, the factors determining the success of pQSAR 2.0 have as yet not been characterized. In this paper we examine the experimental conditions that lead to better pQSAR models. We limit the amount of data available to the method by retraining with decreasing amounts of data and explore the model’s ability to generalize to compounds that have never been assayed. Finally, we look at the properties of training data needed to demonstrate pQSAR improvement.

Biological and medical sciences, Computer science↗