DOE OSTI · 1998416
CRISPR-Cas based system for targeting single-stranded sequences
Abstract
The present invention relates to a CRISPR-Cas based system for targeting nucleic acid sequences. In part, the invention relates to synthetic guiding components for targeting single-stranded sequences, as well as design principles for constructing such components. Also described herein are methods of employing such components, e.g., to repress or activate a desired target within the subject.
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Negrete, Oscar, Doudna, Jennifer A., Strutt, Steven C.. 2023-05-30. CRISPR-Cas based system for targeting single-stranded sequences. https://www.osti.gov/biblio/1998416
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