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DOE OSTI · 23134065

Adipose tissue complement factor B promotes adipocyte maturation

Matsunaga, Hiroaki·Iwashita, Misaki·Shinjo, Takanori·Yamashita, Akiko·Tsuruta, Mitsudai·Nagasaka, Shoichiro·Taniguchi, Ataru·Fukushima, Mitsuo·Watanabe, Naoya·Nishimura, Fusanori
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Abstract

Highlights: • Complement factor B protein is abundantly expressed in inflamed adipose tissue. • Serum complement factor B level showed a correlation with the degree of obesity. • Complement factor B promotes adipocyte maturation and lipid droplet formation. It is well-known that the complement system plays an essential role in host immunity. Observational studies have indicated that complement system-related molecules such as complement factor B (CfB) and other components are correlated with obesity and/or insulin resistance parameters. In this study, we investigated the role of adipocyte-derived CfB in adipose tissue metabolism.

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60 APPLIED LIFE SCIENCESADIPOSE TISSUEINSULINLIPIDSMETABOLIC DISEASESMETABOLISM

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Matsunaga, Hiroaki, Iwashita, Misaki, Shinjo, Takanori, Yamashita, Akiko, Tsuruta, Mitsudai, Nagasaka, Shoichiro, Taniguchi, Ataru, Fukushima, Mitsuo, Watanabe, Naoya, Nishimura, Fusanori. 2018-01-15. Adipose tissue complement factor B promotes adipocyte maturation. https://doi.org/10.1016/j.bbrc.2017.11.069

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