First Multimodal, Three-Dimensional, Image-Guided Total Marrow Irradiation Model for Preclinical Bone Marrow Transplantation Studies

Zuro, Darren; Madabushi, Srideshikan Sargur; Brooks, Jamison; Chen, Bihong T.; Goud, Janagama; others, and

doi:10.1016/j.ijrobp.2021.06.001

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First Multimodal, Three-Dimensional, Image-Guided Total Marrow Irradiation Model for Preclinical Bone Marrow Transplantation Studies

Zuro, Darren·Madabushi, Srideshikan Sargur·Brooks, Jamison·Chen, Bihong T.·Goud, Janagama·others, and

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Abstract

Total marrow irradiation (TMI) has significantly advanced radiation conditioning for hematopoietic cell transplantation in hematologic malignancies by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. However, the relapse rate remains high, and the lack of a preclinical TMI model has hindered scientific advancements. To accelerate TMI translation to the clinic, we developed a TMI delivery system in preclinical models.

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62 RADIOLOGY AND NUCLEAR MEDICINE BONE MARROW IMAGES IRRADIATION NEOPLASMS PATIENTS TOXICITY

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Zuro, Darren, Madabushi, Srideshikan Sargur, Brooks, Jamison, Chen, Bihong T., Goud, Janagama, others, and. 2022-03-05. First Multimodal, Three-Dimensional, Image-Guided Total Marrow Irradiation Model for Preclinical Bone Marrow Transplantation Studies. https://doi.org/10.1016/j.ijrobp.2021.06.001

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