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DOE OSTI · 23200820

Overview and Lessons From the Preclinical Chemoradiotherapy Testing Consortium

Coleman, C. Norman·Bernhard, Eric J.·Espey, Michael G.·Vikram, Bhadrasain
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Abstract

In the current molecular-targeted cancer treatment era, many new agents are being developed so that optimizing therapy with a combination of radiation and drugs is complex. The use of emerging laboratory technologies to further biological understanding of drug-radiation mechanisms of action will enhance the efficiency of the progression from preclinical studies to clinical trials. In 2017, the National Cancer Institute (NCI) solicited proposals through PAR 16-111 to conduct preclinical research combining targeted anticancer agents in the Cancer Therapy Evaluation Program's portfolio with chemoradiation.

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62 RADIOLOGY AND NUCLEAR MEDICINECLINICAL TRIALSCOMBINED THERAPYDRUGSEVALUATIONNEOPLASMSOPTIMIZATION

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Coleman, C. Norman, Bernhard, Eric J., Espey, Michael G., Vikram, Bhadrasain. 2021-12-15. Overview and Lessons From the Preclinical Chemoradiotherapy Testing Consortium. https://doi.org/10.1016/j.ijrobp.2021.07.1709

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