Sub-Ångström-resolution MicroED Using a Direct Detection Camera

Bammes, Benjamin; Zhou, Weijiang; Chiu, Wah

doi:10.1017/s1431927620018401

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Sub-Ångström-resolution MicroED Using a Direct Detection Camera

Bammes, Benjamin·Zhou, Weijiang·Chiu, Wah

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Abstract

The recent development of microcrystal electron diffraction (MicroED) in electron cryo-microscopy (cryo-EM) has addressed many of the challenges of X-ray crystallography [1], filling a long-standing need in organic chemistry for rapid and accurate high-resolution structural characterization [2]. Like X-ray crystallography, this is also a diffraction technique requiring crystalline specimens, but because high energy electrons have a more favorable ration of elastic to inelastic scattering [3], MicroED can acquire data using crystals that are orders of magnitude smaller than those needed for X-ray crystallography—even as small as 50 nm in length [4]. Additionally, the instrumentation required for MicroED is readily available, as many chemistry and biology labs already have access to cryo-capable transmission electron microscopes (TEM).

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Bammes, Benjamin, Zhou, Weijiang, Chiu, Wah. 2020-08-01. Sub-Ångström-resolution MicroED Using a Direct Detection Camera. https://doi.org/10.1017/s1431927620018401

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