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DOE OSTI · 2419790

Programmable 3D Hexagonal Geometry of DNA Tensegrity Triangles

Lu, Brandon·Woloszyn, Karol·Ohayon, Yoel P.·Yang, Bena·Zhang, Cuizheng·Mao, Chengde·Seeman, Nadrian C.·Vecchioni, Simon·Sha, Ruojie
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Abstract

Non-canonical interactions in DNA remain under-explored in DNA nanotechnology. Recently, many structures with non-canonical motifs have been discovered, notably a hexagonal arrangement of typically rhombohedral DNA tensegrity triangles that forms through non-canonical sticky end interactions. Here, in this study, we find a series of mechanisms to program a hexagonal arrangement using: the sticky end sequence; triangle edge torsional stress; and crystallization condition. We showcase cross-talking between Watson–Crick and non-canonical sticky ends in which the ratio between the two dictates segregation by crystal forms or combination into composite crystals. Finally, we develop a method for reconfiguring the long-range geometry of formed crystals from rhombohedral to hexagonal and vice versa. These data demonstrate fine control over non-canonical motifs and their topological self-assembly. This will vastly increase the programmability, functionality, and versatility of rationally designed DNA constructs.

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRYChemistryCrystal engineeringDNA crystalsDNA nanotechnologySelf-assemblyTensegrity triangles

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Lu, Brandon, Woloszyn, Karol, Ohayon, Yoel P., Yang, Bena, Zhang, Cuizheng, Mao, Chengde, Seeman, Nadrian C., Vecchioni, Simon, Sha, Ruojie. 2022-12-15. Programmable 3D Hexagonal Geometry of DNA Tensegrity Triangles. https://doi.org/10.1002/anie.202213451

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