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DOE OSTI · 2511222

Eliater: a Python package for estimating outcomes of perturbations in biomolecular networks

Mohammad-Taheri, Sara·Navada, Pruthvi Prakash·Hoyt, Charles Tapley·Zucker, Jeremy·Sachs, Karen·Gyori, Benjamin M.·Vitek, Olga
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Abstract

We introduce Eliater, a Python package for estimating the effect of perturbation of an upstream molecule on a downstream molecule in a biomolecular network. The estimation takes as input a biomolecular network, observational biomolecular data, and a perturbation of interest, and outputs an estimated quantitative effect of the perturbation. We showcase the functionalities of Eliater in a case study of Escherichia coli transcriptional regulatory network.

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59 BASIC BIOLOGICAL SCIENCES97 MATHEMATICS AND COMPUTING

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BibTeXRIS

Mohammad-Taheri, Sara, Navada, Pruthvi Prakash, Hoyt, Charles Tapley, Zucker, Jeremy, Sachs, Karen, Gyori, Benjamin M., Vitek, Olga. 2024-08-26. Eliater: a Python package for estimating outcomes of perturbations in biomolecular networks. https://doi.org/10.1093/bioinformatics%2Fbtae527

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