DOE OSTI · 2575260
High‐Speed Embedded Ink Writing of Anatomic‐Size Organ Constructs
Abstract
Embedded ink writing (EIW) is an emerging 3D printing technique that fabricates complex 3D structures from various biomaterial inks but is limited to a printing speed of ∼10 mm s −1 due to suboptimal rheological properties of particulate-dominated yield-stress fluids when used as liquid baths. In this work, a particle-hydrogel interactive system to design advanced baths with enhanced yield stress and extended thixotropic response time for realizing high-speed EIW is developed. In this system, the interactions between particle additive and three representative polymeric hydrogels enable the resulting nanocomposites to demonstrate different rheological behaviors. Accordingly, the interaction models for the nanocomposites are established, which are subsequently validated by macroscale rheological measurements and advanced microstructure characterization techniques. Filament formation mechanisms in the particle-hydrogel interactive baths are comprehensively investigated at high printing speeds. To demonstrate the effectiveness of the proposed high-speed EIW method, an anatomic-size human kidney construct is successfully printed at 110 mm s −1 , which only takes ∼4 h. This work breaks the printing speed barrier in current EIW and propels the maximum printing speed by at least 10 times, providing an efficient and promising solution for organ reconstruction in the future.
Explore related subjects
Keep this discovery
Explore connections, maps & timelines
Hua, Weijian [Univ. of Nevada, Reno, NV (United States)], Zhang, Cheng [Univ. of Nevada, Reno, NV (United States); Dalian Univ. of Technology (China)], Cui, Haoran [Univ. of Nevada, Reno, NV (United States)], Mitchell, Kellen [Univ. of Nevada, Reno, NV (United States)], Hensley, Dale K. [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)], Chen, Jihua [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)] (ORCID:0000000168795936), Do, Changwoo [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)] (ORCID:0000000183588417), Raymond, Lily [Univ. of Nevada, Reno, NV (United States)], Coulter, Ryan [Univ. of Nevada, Reno, NV (United States)], Bandala, Erick [Univ. of Nevada, Reno, NV (United States)], Rubbi, Fazlay [Iowa State Univ., Ames, IA (United States)], Chai, Guangrui [Shengjing Hospital of China Medical Univ., Shenyang (China)], Zhang, Zhengyi [Huazhong Univ. of Science and Technology, Wuhan (China)], Liao, Yiliang [Iowa State Univ., Ames, IA (United States)], Zhao, Danyang [Dalian Univ. of Technology (China)], Wang, Yan [Univ. of Nevada, Reno, NV (United States)], Gaharwar, Akhilesh K. [Texas A & M Univ., College Station, TX (United States)], Jin, Yifei [Univ. of Nevada, Reno, NV (United States)] (ORCID:0000000343361802). 2025-02-11. High‐Speed Embedded Ink Writing of Anatomic‐Size Organ Constructs. https://doi.org/10.1002/advs.202405980
Cite the original work for its findings. Save a collection to share your selection of sources.