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DOE OSTI · 2575643

Directed Synthesis of Gold Nanoparticle Superstructures Using Self-Assembling Peptoids Containing Metal-Bonding N-Heterocyclic Carbenes

Ge, Lingcong [Univ. of Vienna (Austria)]·Trinh, Thi Kim Hoang [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)] (ORCID:0000000299065896)·Li, Changning [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)]·Mayer, Florian [Univ. of Vienna (Austria)]·Chin, Jia Min [Univ. of Vienna (Austria)] (ORCID:0000000205401597)·Chen, Chun-Long [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)] (ORCID:000000025584824X)·Reithofer, Michael R. [Univ. of Vienna (Austria)] (ORCID:0000000263281896)
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Abstract

N-Heterocyclic carbene (NHC) ligands, with strong metal-binding affinity, offer a robust platform for constructing organic–inorganic nanohybrids with high stability and tunable properties. However, achieving precise structural control in a simple manner remains challenging. Here, we report a one-pot synthesis of nanohybrids using self-assembling peptoids functionalized with histidine-2-ylidene, which simultaneously enable peptoid assembly and NHC–metal binding. Histidine-2-ylidene-functionalized peptoids were designed to self-assemble and provide NHC binding sites, while AuNPs served as the inorganic component due to NHCs’ strong affinity for gold surfaces. The resulting peptoid-NHC@AuNPs form well-defined vesicles that are characterized by UV–vis spectroscopy, X-ray photoelectron spectroscopy, and electron microscopy. Importantly, the vesicle size and morphology can be tuned via the peptoid sequence or environmental conditions. Further experiments highlight the crucial role of the NHC sites in the formation and stabilization of these nanohybrids. This modular strategy offers a versatile route to fabricating functional NHC-based nanohybrids for potential applications in sensing.

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRYN-heterocyclic carbeneschemical structuregold nanoparticle superstructuresmetal nanoparticlesnanoparticle vesiclesorganic-inorganic nanohybridself organizationself-assembling peptoidstransmission electron microscopyvesicles

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Ge, Lingcong [Univ. of Vienna (Austria)], Trinh, Thi Kim Hoang [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)] (ORCID:0000000299065896), Li, Changning [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)], Mayer, Florian [Univ. of Vienna (Austria)], Chin, Jia Min [Univ. of Vienna (Austria)] (ORCID:0000000205401597), Chen, Chun-Long [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)] (ORCID:000000025584824X), Reithofer, Michael R. [Univ. of Vienna (Austria)] (ORCID:0000000263281896). 2025-07-11. Directed Synthesis of Gold Nanoparticle Superstructures Using Self-Assembling Peptoids Containing Metal-Bonding N-Heterocyclic Carbenes. https://doi.org/10.1021/acs.nanolett.5c02998

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