DOE OSTI · 3013061
A Grassroots Network and Community Roadmap for Interconnected Autonomous Science Laboratories for Accelerated Discovery
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Abstract
Scientific discovery is being revolutionized by AI and autonomous systems, yet current autonomous laboratories remain isolated islands unable to collaborate across institutions. We present the Autonomous Interconnected Science Lab Ecosystem (AISLE), a grassroots network transforming fragmented capabilities into a unified system that shorten the path from ideation to innovation to impact and accelerates discovery from decades to months. AISLE addresses five critical dimensions: (1) cross-institutional equipment orchestration, (2) intelligent data management with FAIR compliance, (3) AI-agent driven orchestration grounded in scientific principles, (4) interoperable agent communication interfaces, and (5) AI/ML-integrated scientific education. By connecting autonomous agents across institutional boundaries, autonomous science can unlock research spaces inaccessible to traditional approaches while democratizing cutting-edge technologies. This paradigm shift toward collaborative autonomous science promises breakthroughs in sustainable energy, materials development, and public health.
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Ferreira da Silva, Rafael [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). National Center for Computational Sciences (NCCS)] (ORCID:0000000217200928), Abolhasani, Milad [North Carolina State University, Raleigh, NC (United States)] (ORCID:0000000288633085), Antonopoulos, Dionysios A. [Argonne National Laboratory (ANL), Argonne, IL (United States)] (ORCID:0000000222385031), Biven, Laura [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)] (ORCID:0000000257558449), Coffee, Ryan [SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)] (ORCID:0000000226198823), Foster, Ian T. [Argonne National Laboratory (ANL), Argonne, IL (United States)] (ORCID:0000000321295269), Hamilton, Leslie [Johns Hopkins University, Silver Spring, MD (United States)] (ORCID:0000000203658321), Jha, Shantenu [Princeton Plasma Physics Laboratory (PPPL), Princeton, NJ (United States)] (ORCID:000000025040026X), Mayer, Theresa [Carnegie Mellon University, Pittsburgh, PA (United States)] (ORCID:0009000021052529), Mintz, Benjamin [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)] (ORCID:0000000240541229), Moore, Robert G. [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)] (ORCID:0000000216085411), Nimer, Salahudin [Johns Hopkins University, Silver Spring, MD (United States)] (ORCID:0000000172983358), Paulson, Noah [Argonne National Laboratory (ANL), Argonne, IL (United States)] (ORCID:0000000235489120), Shin, Woong [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)] (ORCID:0000000172077814), Suter, Frédéric [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)] (ORCID:0000000319021955), Taheri, Mitra [Johns Hopkins University, Baltimore, MD (United States)] (ORCID:0000000153491411), Taufer, Michela [University of Tennessee, Knoxville, TN (United States)] (ORCID:0000000200316377), Washburn, Newell R. [Carnegie Mellon University, Pittsburgh, PA (United States)] (ORCID:0000000178438860). 2025-12-20. A Grassroots Network and Community Roadmap for Interconnected Autonomous Science Laboratories for Accelerated Discovery. https://doi.org/10.1145/3750720.3757292
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