Energetic and structural control of polyspecificity in a multidrug transporter

Miller, Silas T. [Cellular and Molecular Biology Graduate Program, University of Wisconsin–Madison, Madison, WI 53706;; Great Lakes Bioenergy Research Center, University of Wisconsin–Madison, Madison WI 53706; Department of Biochemistry, University of Wisconsin–Madison, Madison, WI 53706]; Raman, Srivatsan [Great Lakes Bioenergy Research Center, University of Wisconsin–Madison, Madison WI 53706; Department of Biochemistry, University of Wisconsin–Madison, Madison, WI 53706; Department of Bacteriology, University of Wisconsin–Madison, Madison, WI 53706; Department of Chemical and Biological Engineering, University of Wisconsin–Madison, Madison, WI 53706]

doi:10.82250/3015690

DOE OSTI · 3015690

Energetic and structural control of polyspecificity in a multidrug transporter

Miller, Silas T. [Cellular and Molecular Biology Graduate Program, University of Wisconsin–Madison, Madison, WI 53706;; Great Lakes Bioenergy Research Center, University of Wisconsin–Madison, Madison WI 53706; Department of Biochemistry, University of Wisconsin–Madison, Madison, WI 53706]·Raman, Srivatsan [Great Lakes Bioenergy Research Center, University of Wisconsin–Madison, Madison WI 53706; Department of Biochemistry, University of Wisconsin–Madison, Madison, WI 53706; Department of Bacteriology, University of Wisconsin–Madison, Madison, WI 53706; Department of Chemical and Biological Engineering, University of Wisconsin–Madison, Madison, WI 53706]

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Abstract

This repository contains scripts and data for reproducing the analyses published in our PNAS publication Energetic and structural control of polyspecificity in a multidrug transporter.

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binding sites efflux transporters mutation polyspecificity Substrate specificity

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Miller, Silas T. [Cellular and Molecular Biology Graduate Program, University of Wisconsin–Madison, Madison, WI 53706;; Great Lakes Bioenergy Research Center, University of Wisconsin–Madison, Madison WI 53706; Department of Biochemistry, University of Wisconsin–Madison, Madison, WI 53706], Raman, Srivatsan [Great Lakes Bioenergy Research Center, University of Wisconsin–Madison, Madison WI 53706; Department of Biochemistry, University of Wisconsin–Madison, Madison, WI 53706; Department of Bacteriology, University of Wisconsin–Madison, Madison, WI 53706; Department of Chemical and Biological Engineering, University of Wisconsin–Madison, Madison, WI 53706]. 2025-10-24. Energetic and structural control of polyspecificity in a multidrug transporter. https://doi.org/10.82250/3015690

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