DOE OSTI · 3575292
Identification of ligands for E3 ligases with restricted expression using fragment-based methods
Abstract
NMR-based screening identified fragment hits that bind to E3 ligases that are preferentially expressed in cancer tissues.
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Waterson, Alex G. [Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA] (ORCID:0000000201535723), Lehmann, Brian D. [Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA] (ORCID:0000000304075248), Lu, Zhenwei [Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA], Sensintaffar, John L. [Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA], Olejniczak, Edward T. [Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA], Zhao, Bin [Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA], Rietz, Tyson [Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA], Payne, William G. [Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA], Phan, Jason [Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA], Fesik, Stephen W. [Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA] (ORCID:0000000159576192). 2025-01-01. Identification of ligands for E3 ligases with restricted expression using fragment-based methods. https://doi.org/10.1039/d5cb00198f
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