DOE OSTI · 3731625
Vision and Development of a Design, Implementation, and Verification Automation (DIVA) Software Platform for DNA Construction
Abstract
Abstract DNA construction, while a prerequisite to many biological endeavors, is often a time-consuming distraction from an individual’s primary research objectives. We envisioned that with the right software infrastructure and cultural mindset, a single person could execute in parallel the batched DNA construction tasks of an entire research institute, at scales realizing efficiency gains through process and laboratory automation. In pursuit of this vision, we developed the Design, Implementation, and Verification Automation (DIVA) software platform. DIVA’s web interface enables researchers to design DNA constructs (using visual biological computer-aided design tools and biological parts repositories), submit designs for construction to dedicated staff, and track DNA construction as it progresses. DIVA supports the dedicated staff through the DNA construction process and records both successful and unsuccessful attempts toward improving the overall process. The platform is publicly available at public-diva.jbei.org and its open-source code through github.com/JBEI/DIVA.
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Plahar, Hector [DOE Agile BioFoundry , , ,; DOE Joint BioEnergy Institute , , ,; Lawrence Berkeley National Laboratory , , , ,], Lane, Stephen D. [DOE Agile BioFoundry , , ,; DOE Joint BioEnergy Institute , , ,; Sandia National Laboratories , , ,], Stawski, Nina [DOE Joint BioEnergy Institute , , ,; Lawrence Berkeley National Laboratory , , , ,], Simirenko, Lisa [Lawrence Berkeley National Laboratory , , , ,], Tapaswi, Manjiri [DOE Joint BioEnergy Institute , , ,; Lawrence Berkeley National Laboratory , , , ,], Kuo, Rita [DOE Agile BioFoundry , , ,; DOE Joint BioEnergy Institute , , ,; Lawrence Berkeley National Laboratory , , , ,], Goyal, Garima [DOE Agile BioFoundry , , ,; DOE Joint BioEnergy Institute , , ,; Lawrence Berkeley National Laboratory , , , ,], Hillson, Nathan J. [DOE Agile BioFoundry , , ,; DOE Joint BioEnergy Institute , , ,; Lawrence Berkeley National Laboratory , , , ,] (ORCID:0000000291693978), Petzold, Christopher J. [DOE Agile BioFoundry , , ,; DOE Joint BioEnergy Institute , , ,; Lawrence Berkeley National Laboratory , , , ,] (ORCID:0000000282705228). 2026-07-07. Vision and Development of a Design, Implementation, and Verification Automation (DIVA) Software Platform for DNA Construction. https://doi.org/10.1021/acssynbio.6c00197
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