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NASA NTRS1993

Use of ultrasound in altitude decompression modeling

A model that predicts the probability of developing decompression sickness (DCS) with various denitrogenation schedules is being developed by the Armstrong Laboratory, using human data from previous exposures. It was noted that refinements are needed to improve the accuracy and scope of the model. A commercially developed ultrasonic echo imaging system is being used in this model development. Using this technique, bubbles images from a subject at altitude can be seen in the gall bladder, hepatic veins, vena cava, and chambers of the heart. As judged by their motion and appearance in the vena cava, venous bubbles near the heart range in size from 30 to 300 M. The larger bubbles skim along the top, whereas the smaller ones appear as faint images near the bottom of the vessel. Images from growing bubbles in a model altitude chamber indicate that they grow rapidly, going from 20 to 100 M in 3 sec near 30,000 ft altitude. Information such as this is valuable in verifying those aspects of the DCS model dealing with bubble size, their growth rate, and their site of origin.

Olson, Robert M.↗

NASA NTRS1992

Design and development of the second generation Mars Habitat

The second generation of Mars Habitat is to be utilized as an advanced permanent base for 20 crew members to live on Mars for a period of 6-12 months. It is designed to be a self-contained environment accommodating five main facilities: living, working, service, medical, and a greenhouse. The objective of the design is to create a comfortable, safe, living environment. Hexamars-2 and Lavapolis-2 are two different concepts for the advanced Mars Habitat. The design team assumes there will be an initial habitat located near or on the site from earlier missions that satisfies the requirement for a short-term habitation for the crew to use while constructing Hexamars-2 or Lavapolis-2. Prefabricated structures and materials will be shipped to the site before the long-term crew members arrive. Partial construction and preparation for the long-term habitat will be done by crew members or robotics from a previous mission. The construction of the long-term base will occur in phases. Hexamars-2 consists of six sphere-shaped inflatable modules that will be partially buried below the Martian surface. The construction of each sphere will occur in ten steps. Shape charges will be used to create the crater in which the spherical structure will be placed. The interior core will be unloaded and put into place followed by the exterior structure. The foundation will be filled, the interior bladder will be inflated, floor-to-floor joists connected, and sand pockets filled. Finally, the life support system and interior partitions are put in place. Each sphere consists of three levels of which the lower level will be safe haven. Particular attention is given to structural support, the dominance of internal pressure, the process of construction, and human factors.

Sabouni, Ikhlas↗

NASA NTRS1994

Composite hot drape forming

This program was initiated to replace labor-intensive ply-by-ply layup of composite I-beam posts and angle stiffeners used in the Space Station Freedom (SSF) rack structure. Hot drape forming (HDF) has been successfully implemented by BCAG for 777 composite I-stringers and by Bell Helicopter/Textron for the V-22 I-stingers. The two companies utilize two vastly different approaches to the I-beam fabrication process. A drape down process is used by Bell Helicopter where the compacted ply charge is placed on top of a forming mandrel and heated. When the heated ply charge reached a set temperature, vacuum pressure is applied and the plies are formed over the mandrel. The BCAG 777 process utilizes an inverted forming process where the ply stack is placed on a forming table and the mandrel is inverted and placed upon the ply stack. A heating and vacuum bladder underneath the ply stack form the play stack up onto the mandrels after reaching the temperature setpoint. Both methods have their advantages, but the drape down process was selected for SSF because it was more versatile and could be fabricated from readily available components.

Ott, Thomas↗

NASA NTRS1994

Comparative performance of a modified Space Shuttle Reentry Anti-G Suit (REAGS) with and without pressure socks

In a prior study, the Armstrong Laboratory (AL) demonstrated that +G(sub z) protection during simulated shuttle reentry could be improved with an extended coverage anti-G suit with pressure socks but no abdominal bladder (REAGS). In a subsequent study conducted at the NASA Johnson Space Center it was shown that REAGS had a down side which included restricted mobility (during simulated shuttle egress) and a larger boot size needed for the pressure socks. The present study was conducted using a modified REAGS to increase mobility during egress. The size of the crotch opening was increased, and the fabric covering the buttocks was replaced with more elastic material. Six healthy male members of the AL centrifuge panel served as subjects for the study. As in the earlier study, subjects received 20 to 35 mg of IV Lasix approximately 6 hours before being exposed to a simulated space shuttle reentry +G(sub z) profile on the AL centrifuge, which induced a mean weight loss of 2.8 percent, range 2.1 percent to 3.7 percent. The REAGS was inflated to 1.0 psig 10 minutes prior to G onset. The G-profile was identical to that used in the previous REAGS study. Physiologic parameters monitored were also the same, i.e., eye-level systolic blood pressure (ELBP) using the Finapres digital cuff technique and heart rate and rhythm. Subjective comments were obtained from questionnaires administered after the increased G exposure. Systolic ELBP was maintained at 60 mm Hg or above by pressurizing the anti-G suit in 0.5 psig increments up to a maximum pressure of 2.5 psig. There were no significant differences in mean G-suit pressure required to maintain systolic ELBP at 60 mm Hg or above between the REAGS worn with and without pressure socks. Maximum mean G-levels achieved during the GOR were also the same under both experimental conditions, i.e., 4.7 G with socks and 4.6 G without socks. These G-levels were essentially the same as recorded earlier with the unmodified REAGS. There were no significant differences in comfort rating during the G exposure assigned by subjects when they wore the modified REAGS with or without the pressure socks.

Krutz, R. W., Jr.↗

NASA NTRS1991

VERDEX: A virtual environment demonstrator for remote driving applications

One of the key areas of the National Advanced Robotics Centre's enabling technologies research program is that of the human system interface, phase 1 of which started in July 1989 and is currently addressing the potential of virtual environments to permit intuitive and natural interactions between a human operator and a remote robotic vehicle. The aim of the first 12 months of this program (to September, 1990) is to develop a virtual human-interface demonstrator for use later as a test bed for human factors experimentation. This presentation will describe the current state of development of the test bed, and will outline some human factors issues and problems for more general discussion. In brief, the virtual telepresence system for remote driving has been designed to take the following form. The human operator will be provided with a helmet-mounted stereo display assembly, facilities for speech recognition and synthesis (using the Marconi Macrospeak system), and a VPL DataGlove Model 2 unit. The vehicle to be used for the purposes of remote driving is a Cybermotion Navmaster K2A system, which will be equipped with a stereo camera and microphone pair, mounted on a motorized high-speed pan-and-tilt head incorporating a closed-loop laser ranging sensor for camera convergence control (currently under contractual development). It will be possible to relay information to and from the vehicle and sensory system via an umbilical or RF link. The aim is to develop an interactive audio-visual display system capable of presenting combined stereo TV pictures and virtual graphics windows, the latter featuring control representations appropriate for vehicle driving and interaction using a graphical 'hand,' slaved to the flex and tracking sensors of the DataGlove and an additional helmet-mounted Polhemus IsoTrack sensor. Developments planned for the virtual environment test bed include transfer of operator control between remote driving and remote manipulation, dexterous end effector integration, virtual force and tactile sensing (also the focus of a current ARRL contract, initially employing a 14-pneumatic bladder glove attachment), and sensor-driven world modeling for total virtual environment generation and operator-assistance in remote scene interrogation.

Stone, Robert J.↗

NASA NTRS1995

An inflight refill unit for replenishing research animal drinking water

This paper presents the design process and development approach for a method of maintaining sufficient quantities of water for research animals during a Shuttle mission of long duration. An inflight refill unit (IRU) consisting of two major subsystems, a fluid pumping unit (FPU) and a collapsible water reservoir (CWR), were developed. The FPU provides the system measurement and controls, pump, water lines, and plumbing necessary to collect water coming into the unit from the potable water system and pump it out into the RAHF drinking water tanks. The CWR is a Kevlar (TM) reinforced storage bladder connected to the FPU, which has a capacity of 6 liters in its expanded volume and functions to store the water collected from the potable water system, allowing for transport of the water back to the Spacelab where it is pumped into each of two research animal holding facilities. Additional components of the IRU system include the inlet and outlet fluid hoses, a power cable for providing 29V direct current spacecraft electrical power to the pump within the FPU, a tether system for the unit when in use in Spacelab, and an adapter for mating the unit to the orbiter waste collection system in order to dump excess water after use in Spacelab.

Savage, P. D.↗

NASA NTRS1990

The subscale orbital fluid transfer experiment

The Subscale Orbital Fluid Transfer Experiment (SOFTE) is a planned Shuttle Orbiter fluid transfer experiment. CASP (Center for Advanced Space Propulsion) performed certain aspects of the conceptual design of this experiment. The CASP work consisted of the conceptual design of the optical system, the search for alternative experimental fluids, the determination of the flow meter specifications and the examination of materials to use for a bladder that will empty one of the tanks in the experiment.

Collins, Frank G.↗

NASA NTRS1994

Development of an In-Flight Refill Unit for Replenishing Research Animal Drinking Water

The Spacelab Life Sciences 2 (SLS-2) mission became NASA's longest duration Shuttle mission, lasting fourteen days, when Columbia landed on 1 Nov. 1993. Located within the Spacelab were a total of 48 laboratory rats which were housed in two Research Animal Holding Facilities (RAHF's) developed by the Space Life Sciences Payloads Office (SLSPO) at Ames Research Center. In order to properly maintain the health and well-being of these important research animals, sufficient quantities of food and water had to be available for the duration of the mission. An inflight Refill Unit was developed by the SLSPO to replenish the animals' drinking water inflight using the Shuttle potable water system in the middeck galley as the source of additional water. The Inflight Refill Unit consists of two major subsystems, a Fluid Pumping Unit (FPU) and a Collapsible Water Reservoir (CWR). The FPU provides the system measurement and controls, pump, water lines, and plumbing necessary to collect water coming into the unit from the potable water system and pump it out and into the RAHF drinking water tanks. The CWR is a Kevlar(trademark) reinforced storage bladder, connected to the FPU, which has a capacity of 6 liters in its expanded volume and functions to store the water collected from the potable water system and allows for the transport of the water back to the Spacelab where it is pumped into each of two RAHFs. Additional components of the FPU system include the inlet and outlet fluid hoses, a power cable for providing 28 volt direct current spacecraft electrical power to the pump within the FPU, a tether system for the unit when in use in Spacelab, and an adapter for mating the unit to the orbiter waste collection system in order to dump excess water after use in Spacelab. This paper will present the design process and development approach for the lnflight Refill Unit, define some of the key design issues which had to be addressed, and summarize the inflight operational performance of the unit during the SLS-2 mission.

Savage, P. D.↗

NASA NTRS2001

TransHab Materials Selection

A viewgraph presentation gives an overview of the materials selection for the TransHab, the habitation module on the International Space Station (ISS). Details are given on the location of TransHab on the ISS, the multilayer inflatable shell that surrounds the module, the materials requirements (including information on the expected thermal environment), the materials selection challenges, the bladder materials requirements and testing, and meteoroid/debris shielding material.

Pedley, M. D.↗

NASA NTRS1991

Spinal Bracing

Dr. Arthur Copes of the Copes Foundation, Baton Rouge, LA, says that 35 percent of the 50 technical reports he received from the NASA/Southern University Industrial Applications Center in Baton Rouge and the Central Industrial Applications Center, Durant, OK, were vital to the development of his Copes Scoliosis Braces, which are custom designed and feature a novel pneumatic bladder that exerts constant corrective pressure to the torso to slowly reduce or eliminate the spinal curve.

Source record↗

NASA NTRS2002

Protecting Space Travelers from Kidney Stones: Renal Stone Risk During Space Flight

Renal stones, popularly known as kidney or bladder stones, are small rock-like objects formed in the kidneys or urinary tract by deposits of calcium and other minerals. The problem arises when the stones block the drainage of the kidney, resulting in urinary obstruction and pain. Passing these stones can be one of the most painful experiences a person will endure so doctors often prescribe pain relievers to ease the experience. Drinking plenty of fluids, which help flush waste out of the body, and eating a well-balanced diet are the first steps to preventing stones. For individuals at risk, this may not be enough, and a doctor may recommend a special diet and medications. Unfortunately, approximately 60 percent of people who have had a renal stone will experience a recurrence. This is particularly true of men, who are four to five times more likely to develop stones than women. Renal stones do not discriminate based on age; even children are at risk. Astronauts are particularly at risk of developing renal stones because they lose bone and muscle mass; calcium, other minerals, and protein normally used for bone and muscle end up in the bloodstream and then in the kidneys. Without plenty of fluid to wash them away, crystals can form and then grow into stones. This factor compounds the risk for astronauts, since they also perceive that they are less thirsty in space and will drink less than normal during the mission. To minimize all of these factors, doctors must instead treat the stone-forming compounds with medication. This study will use potassium citrate to reduce the risk of stone formation. Renal stones are never convenient, but they are a particular concern for astronauts who have limited access to treatment during flight. Researchers are examining how earthbound preventions for renal stone formation work in flight, ensuring missions are not ended prematurely due to this medical condition. During STS-107, earthbound preventions and treatments become astronauts' gain.

Whitson, Peggy↗

NASA NTRS2002

Collapsible Cryogenic Storage Vessel Project

Collapsible cryogenic storage vessels may be useful for future space exploration missions by providing long-term storage capability using a lightweight system that can be compactly packaged for launch. Previous development efforts have identified an 'inflatable' concept as most promising. In the inflatable tank concept, the cryogen is contained within a flexible pressure wall comprised of a flexible bladder to contain the cryogen and a fabric reinforcement layer for structural strength. A flexible, high-performance insulation jacket surrounds the vessel. The weight of the tank and the cryogen is supported by rigid support structures. This design concept is developed through physical testing of a scaled pressure wall, and through development of tests for a flexible Layered Composite Insulation (LCI) insulation jacket. A demonstration pressure wall is fabricated using Spectra fabric for reinforcement, and burst tested under noncryogenic conditions. An insulation test specimens is prepared to demonstrate the effectiveness of the insulation when subject to folding effects, and to examine the effect of compression of the insulation under compressive loading to simulate the pressure effect in a nonrigid insulation blanket under the action atmospheric pressure, such as would be seen in application on the surface of Mars. Although pressure testing did not meet the design goals, the concept shows promise for the design. The testing program provides direction for future development of the collapsible cryogenic vessel concept.

Fleming, David C.↗

NASA NTRS2003

Radiation-induced second cancers: the impact of 3D-CRT and IMRT

Information concerning radiation-induced malignancies comes from the A-bomb survivors and from medically exposed individuals, including second cancers in radiation therapy patients. The A-bomb survivors show an excess incidence of carcinomas in tissues such as the gastrointestinal tract, breast, thyroid, and bladder, which is linear with dose up to about 2.5 Sv. There is great uncertainty concerning the dose-response relationship for radiation-induced carcinogenesis at higher doses. Some animal and human data suggest a decrease at higher doses, usually attributed to cell killing; other data suggest a plateau in dose. Radiotherapy patients also show an excess incidence of carcinomas, often in sites remote from the treatment fields; in addition there is an excess incidence of sarcomas in the heavily irradiated in-field tissues. The transition from conventional radiotherapy to three-dimensional conformal radiation therapy (3D-CRT) involves a reduction in the volume of normal tissues receiving a high dose, with an increase in dose to the target volume that includes the tumor and a limited amount of normal tissue. One might expect a decrease in the number of sarcomas induced and also (less certain) a small decrease in the number of carcinomas. All around, a good thing. By contrast, the move from 3D-CRT to intensity-modulated radiation therapy (IMRT) involves more fields, and the dose-volume histograms show that, as a consequence, a larger volume of normal tissue is exposed to lower doses. In addition, the number of monitor units is increased by a factor of 2 to 3, increasing the total body exposure, due to leakage radiation. Both factors will tend to increase the risk of second cancers. Altogether, IMRT is likely to almost double the incidence of second malignancies compared with conventional radiotherapy from about 1% to 1.75% for patients surviving 10 years. The numbers may be larger for longer survival (or for younger patients), but the ratio should remain the same.

Review, Tutorial↗

NASA NTRS2002

Probability of cell hits in selected organs and tissues by high-LET particles at the ISS orbit

The fluence of high-LET particles (HLP) with LET infinity H2O greater than 15 keV micrometers-1 in selected organs and tissues were measured with plastic nuclear track detectors using a life-size human phantom on the 9th Shuttle-Mir Mission (STS-91). The planar-track fluence of HLP during the 9.8-day mission ranged from 1.9 x 10(3) n cm-2 (bladder) to 5.1 x 10(3) n cm-2 (brain) by a factor of 2.7. Based on these data, a probability of HLP hits to a matured cell of each organ or tissue was roughly estimated for a 90-day ISS mission. In the calculation, all cells were assumed to be spheres with a geometric cross-sectional area of 500 micrometers2 and the cell-hit frequency from isotropic space radiation can be described by the Poisson-distribution function. As results, the probability of one or more than 1 hit to a single cell by HLP for 90 days ranged from 17% to 38%; that of two or more than 2 hits was estimated to be 1.3-8.2%. c2002 COSPAR. Published by Elsevier Science Ltd. All rights reserved.

NASA Discipline Radiation Health↗

NASA NTRS1999

Multimodality stereotactic brain tissue identification: the NASA smart probe project

Real-time tissue identification can benefit procedures such as stereotactic brain biopsy, functional neurosurgery and brain tumor excision. Optical scattering spectroscopy has been shown to be effective at discriminating cancer from noncancerous conditions in the colon, bladder and breast. The NASA Smart Probe extends the concept of 'optical biopsy' by using neural network techniques to combine the output from 3 microsensors contained within a cannula 2. 7 mm in diameter (i.e. the diameter of a stereotactic brain biopsy needle). Experimental data from 5 rats show the clear differentiation between tissues such as brain, nerve, fat, artery and muscle that can be achieved with optical scattering spectroscopy alone. These data and previous findings with other modalities such as (1) analysis of the image from a fiberoptic neuroendoscope and (2) the output from a microstrain gauge suggest the Smart Probe multiple microsensor technique shows promise for real-time tissue identification in neurosurgical procedures. Copyright 2000 S. Karger AG, Basel.

Non-programmatic↗

NASA NTRS1995

Risk cross sections and their application to risk estimation in the galactic cosmic-ray environment

Radiation risk cross sections (i.e. risks per particle fluence) are discussed in the context of estimating the risk of radiation-induced cancer on long-term space flights from the galactic cosmic radiation outside the confines of the earth's magnetic field. Such quantities are useful for handling effects not seen after low-LET radiation. Since appropriate cross-section functions for cancer induction for each particle species are not yet available, the conventional quality factor is used as an approximation to obtain numerical results for risks of excess cancer mortality. Risks are obtained for seven of the most radiosensitive organs as determined by the ICRP [stomach, colon, lung, bone marrow (BFO), bladder, esophagus and breast], beneath 10 g/cm2 aluminum shielding at solar minimum. Spectra are obtained for excess relative risk for each cancer per LET interval by calculating the average fluence-LET spectrum for the organ and converting to risk by multiplying by a factor proportional to R gamma L Q(L) before integrating over L, the unrestricted LET. Here R gamma is the risk coefficient for low-LET radiation (excess relative mortality per Sv) for the particular organ in question. The total risks of excess cancer mortality obtained are 1.3 and 1.1% to female and male crew, respectively, for a 1-year exposure at solar minimum. Uncertainties in these values are estimated to range between factors of 4 and 15 and are dominated by the biological uncertainties in the risk coefficients for low-LET radiation and in the LET (or energy) dependence of the risk cross sections (as approximated by the quality factor). The direct substitution of appropriate risk cross sections will eventually circumvent entirely the need to calculate, measure or use absorbed dose, equivalent dose and quality factor for such a high-energy charged-particle environment.

NASA Discipline Radiation Health↗

NASA NTRS1994

Intramuscular pressures beneath elastic and inelastic leggings

Leg compression devices have been used extensively by patients to combat chronic venous insufficiency and by astronauts to counteract orthostatic intolerance following spaceflight. However, the effects of elastic and inelastic leggings on the calf muscle pump have not been compared. The purpose of this study was to compare in normal subjects the effects of elastic and inelastic compression on leg intramuscular pressure (IMP), an objective index of calf muscle pump function. IMP in soleus and tibialis anterior muscles was measured with transducer-tipped catheters. Surface compression between each legging and the skin was recorded with an air bladder. Subjects were studied under three conditions: (1) control (no legging), (2) elastic legging, and (3) inelastic legging. Pressure data were recorded for each condition during recumbency, sitting, standing, walking, and running. Elastic leggings applied significantly greater surface compression during recumbency (20 +/- 1 mm Hg, mean +/- SE) than inelastic leggings (13 +/- 2 mm Hg). During recumbency, elastic leggings produced significantly higher soleus IMP of 25 +/- 1 mm Hg and tibialis anterior IMP of 28 +/- 1 mm Hg compared to 17 +/- 1 mm Hg and 20 +/- 2 mm Hg, respectively, generated by inelastic leggings and 8 +/- 1 mm Hg and 11 +/- 1 mm Hg, respectively, without leggings. During sitting, walking, and running, however, peak IMPs generated in the muscular compartments by elastic and inelastic leggings were similar. Our results suggest that elastic leg compression applied over a long period in the recumbent posture may impede microcirculation and jeopardize tissue viability.(ABSTRACT TRUNCATED AT 250 WORDS).

Clinical Trial↗

NASA NTRS1992

Decreased heterotopic osteogenesis in vitamin-D-deficient, but normocalcemic guinea pigs

The effect of vitamin D deficiency unhampered by hypocalcemia on de novo bone formation was studied in guinea pigs. Heterotopic induction of osteogenesis was evaluated 4 weeks after intramuscular transplantation of allogenic urinary bladder transitional epithelium from vitamin-D-repleted (+D) donors into +D and -D recipients. In -D recipients the frequency of osteogenesis and the amount of induced bone were significantly diminished; induced bone was less mature, scantly cellular woven bone poorly repopulated with bone marrow. No effect of vitamin D deficiency on orthotopic bone growth and on mineralization of orthotopic and heterotopically induced bone was observed. It is proposed that in addition to inducing factors (BMPs, growth factors) which may be responsible for transformation of mesenchymal cells to osteoprogenitor cells, normal concentrations of 1,25-(OH)2D3 may be required for proliferation and further differentiation of these cells into osteoblasts and for expression of genes engaged in extracellular matrix formation and maturation.

NASA Discipline Musculoskeletal↗