Search NASA⌕ Search

SEARCH · Search NASA

Results for “Derived”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 181 records · Page 10
All sourcesNASA NTRSDOE OSTI
DOE OSTI2023

Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis

Human schistosomiasis is a neglected tropical disease caused by Schistosoma mansoni, S. haematobium, and S. japonicum. Praziquantel (PZQ) is the method of choice for treatment. Due to constant selection pressure, there is an urgent need for new therapies for schistosomiasis. Previous treatment of S. mansoni included the use of oxamniquine (OXA), a drug that is activated by a schistosome sulfotransferase (SULT). Guided by data from X-ray crystallography and Schistosoma killing assays more than 350 OXA derivatives were designed, synthesized, and tested. We were able to identify CIDD-0150610 and CIDD-0150303 as potent derivatives in vitro that kill (100%) of all three Schistosoma species at a final concentration of 71.5 μM. We evaluated the efficacy of the best OXA derivates in an in vivo model after treatment with a single dose of 100 mg/kg by oral gavage. The highest rate of worm burden reduction was achieved by CIDD -150303 (81.8%) against S. mansoni, CIDD-0149830 (80.2%) against S. haematobium and CIDD-066790 (86.7%) against S. japonicum. We have also evaluated the ability of the derivatives to kill immature stages since PZQ does not kill immature schistosomes. CIDD-0150303 demonstrated (100%) killing for all life stages at a final concentration of 143 μM in vitro and effective reduction in worm burden in vivo against S. mansoni. To understand how OXA derivatives fit in the SULT binding pocket, X-ray crystal structures of CIDD-0150303 and CIDD-0150610 demonstrate that the SULT active site will accommodate further modifications to our most active compounds as we fine tune them to increase favorable pharmacokinetic properties. Treatment with a single dose of 100 mg/kg by oral gavage with co-dose of PZQ + CIDD-0150303 reduced the worm burden of PZQ resistant parasites in an animal model by 90.8%. Therefore, we conclude that CIDD-0150303, CIDD-0149830 and CIDD-066790 are novel drugs that overcome some of PZQ limitations, and CIDD-0150303 can be used with PZQ in combination therapy.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2020

Analytically Derived Piezoelectric Ejecta Data Transformations, with Implications for Claims of Experimentally Observed Self-Similarity

Building upon a previously documented analytic formalism, we derive a set of data transformations that relate piezoelectrically inferred time-dependent ejecta masses, dynamical ejecta cloud densities, and "radiographic" ejecta cloud density distributions. These transformation rules are derived rigorously, with careful attention to the assumption of instant ejecta production which is inherent in the piezoelectric mass inference procedure. Some of these relationships have not appeared previously in the literature, including solutions for the unique ejecta velocity distribution and radiographic ejecta cloud density distribution consistent with the instant-production assumption for a given piezoelectrically inferred mass dataset. In deriving the latter, we prove that—again subject to the ubiquitous instant-creation assumption—measurements at a single sensor are sufficient to determine properties of the ejecta cloud everywhere at all times. Other data transformation relationships have appeared in the literature without a rigorous derivation, or have been stated in forms that obscure the key mathematical relationships. We apply these results to arguments for self-similar ejecta cloud evolution, thereby deriving mathematical expressions by which claims of self-similarity may be examined. We prove that one analysis used in the literature to claim experimental evidence of a short ejecta production timescale—and consequently of self-similar cloud evolution—in fact places no constraint the ejecta production interval and therefore does not support the associated conclusion. We also provide a potentially useful uniqueness proof.

30 DIRECT ENERGY CONVERSION↗
DOE OSTI2022

Elevations in Tumor Necrosis Factor Alpha and Interleukin 6 From Neuronal-Derived Extracellular Vesicles in Repeated Low-Level Blast Exposed Personnel

The purpose of this pilot study was to determine if military service members with histories of hundreds to thousands of low-level blast exposures (i. e., experienced breachers) had different levels of serum and neuronal-derived extracellular vesicle (EV) concentrations of interleukin (IL)-6, IL-10, and tumor necrosis factor alpha (TNFα), compared to matched controls, and if these biomarkers related to neurobehavioral symptoms. Participants were experienced breachers (n = 20) and matched controls without blast exposures (n = 14). Neuronal-derived EVs were isolated from serum and identified with mouse anti-human CD171. Serum and neuronal-derived EVs were analyzed for IL-6, IL-10, and TNFα using an ultra-sensitive assay. Serum TNFα concentrations were decreased in breachers when compared to control concentrations (p < 0.01). There were no differences in serum concentrations of IL-6, IL-10, or the IL-6/IL-10 ratio between breachers and controls (p's > 0.01). In neuronal-derived EVs, TNFα and IL-6 levels were increased in breachers compared to controls (p's < 0.01), and IL-10 levels were decreased in the breacher group compared to controls (p < 0.01). In breachers the IL-6/IL-10 ratio in neuronal-derived EVs was higher compared to controls, which correlated with higher total Rivermead Post-concussion Questionnaire (RPQ) scores (p's < 0.05). These findings suggest that exposure of personnel to high numbers of low-level blast over a career may result in enduring central inflammation that is associated with chronic neurological symptoms. The data also suggest that peripheral markers of inflammation are not necessarily adequate surrogates for central neuroinflammation.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1972

Flight-determined derivatives and dynamic characteristics of the CV-990 airplane

Flight-determined longitudinal and lateral-directional stability and control derivatives are presented for the CV-990 airplane for various combinations of Mach number, altitude, and flap setting throughout the flight envelope up to a Mach number of 0.87. Also presented are the dynamic characteristics of the aircraft calculated from the flight-obtained derivatives and the measured phugoid characteristics. The derivative characteristics were obtained from flight records of longitudinal and lateral-directional transient oscillation maneuvers by using a modified Newton-Raphson digital derivative determination technique. Generally the derivatives exhibited consistent variation with lift coefficient in the low-speed data and with Mach number and altitude in the high-speed data. Many also varied with flap deflection, notably spoiler effectiveness and directional stability.

Gilyard, G. B.↗
NASA NTRS1974

Wind-tunnel investigation to determine the low speed yawing stability derivatives of a twin jet fighter model at high angles of attack

An investigation was conducted to determine the low-speed yawing stability derivatives of a twin-jet fighter airplane model at high angles of attack. Tests were performed in a low-speed tunnel utilizing variable-curvature walls to simulate pure yawing motion. The results of the study showed that at angles of attack below the stall the yawing derivatives were essentially independent of the yawing velocity and sideslip angle. However, at angles of attack above the stall some nonlinear variations were present and the derivatives were strongly dependent upon sideslip angle. The results also showed that the rolling moment due to yawing was primarily due to the wing-fuselage combination, and that at angles of attack below the stall both the vertical and horizontal tails produced significant contributions to the damping in yaw. Additionally, the tests showed that the use of the forced-oscillation data to represent the yawing stability derivatives is questionable, at high angles of attack, due to large effects arising from the acceleration in sideslip derivatives.

Coe, P. L., Jr.↗
NASA NTRS1974

Measurement of dynamic cross-derivatives due to pitching and yawing

A novel wind-tunnel apparatus is described with which all the 12 static and dynamic moment derivatives due to pitching and yawing can be obtained at angles of attack up to 40 deg and in the presence of some sideslip. The experimental technique and the data reduction procedure are discussed, and preliminary data on dynamic derivatives for an aircraft-like configuration at M ? 0.70 are presented. It is shown that in the range of angle of attack investigated, some rather large variations occur in both the two direct damping derivatives and some of the dynamic cross-derivatives; the latter, however, remain small as compared to the corresponding direct damping derivatives (in general less than 10%).

Orlik-Rueckemann, K. J.↗
NASA NTRS1976

Flight data identification of six degree-of-freedom stability and control derivatives of a large crane type helicopter

Flight test data from a large 'crane' type helicopter were collected and processed for the purpose of identifying vehicle rigid body stability and control derivatives. The process consisted of using digital and Kalman filtering techniques for state estimation and Extended Kalman filtering for parameter identification, utilizing a least squares algorithm for initial derivative and variance estimates. Data were processed for indicated airspeeds from 0 m/sec to 152 m/sec. Pulse, doublet and step control inputs were investigated. Digital filter frequency did not have a major effect on the identification process, while the initial derivative estimates and the estimated variances had an appreciable effect on many derivative estimates. The major derivatives identified agreed fairly well with analytical predictions and engineering experience. Doublet control inputs provided better results than pulse or step inputs.

Tomaine, R. L.↗
NASA NTRS1976

Derivation of the Navier-Stokes equation

The proposed approach to the derivation of the Navier-Stokes equation is thought to be more plausible and easier to understand than other derivations that can be found in works on fluid mechanics. The tensor character of the stress is central to the derivation. In particular, a linear relation between stress and strain rate is assumed only for the shear, rather than for the full stress tensor as is done in most other derivations. An assumption for the shear is naturally simpler and easier to verify experimentally. The use of tensor analysis is shown to greatly simplify the derivation.

Deissler, R. G.↗
NASA NTRS1983

Derivation of the fundamental equation of sound generated by moving aerodynamic surfaces

Ffowcs Williams and Hawkings (1969) based their derivation of the fundamental equation of the sound generated by arbitrarily moving aerodynamic surfaces on the study of mass and momentum balance of a control volume imbedding a mathematical surface(s) exactly corresponding to real surface(s). These investigators also sketched an alternative method, employing generalized functions, for its derivation. This latter method, which was later developed by Farassat (1975), is purely mathematical and formal. Goldstein (1976) used the free-space Green function to produce an implicit derivation of the Ffowcs Williams and Hawkings equation. In the study presented here, Lowson's (1965) concept of moving point singularities is generalized to moving surface singularities, and a new derivation is given of the fundamental equation. The derivation is based on topological considerations of the underlying space, the fluid medium, and the integral properties of the Dirac delta function.

Aggarwal, H. R.↗
NASA NTRS1983

Higher-order derivative correlations and the alignment of small-scale structures in isotropic numerical turbulence

In a three dimensional simulation higher order derivative correlations, including skewness and flatness factors, are calculated for velocity and passive scalar fields and are compared with structures in the flow. The equations are forced to maintain steady state turbulence and collect statistics. It is found that the scalar derivative flatness increases much faster with Reynolds number than the velocity derivative flatness, and the velocity and mixed derivative skewness do not increase with Reynolds number. Separate exponents are found for the various fourth order velocity derivative correlations, with the vorticity flatness exponent the largest. Three dimensional graphics show strong alignment between the vorticity, rate of strain, and scalar-gradient fields. The vorticity is concentrated in tubes with the scalar gradient and the largest principal rate of strain aligned perpendicular to the tubes. Velocity spectra, in Kolmogorov variables, collapse to a single curve and a short minus 5/3 spectral regime is observed.

Kerr, R. A.↗
NASA NTRS1981

Longitudinal stability and control derivatives obtained from flight data of a PA-30 aircraft

In order to obtain reliable and accurate values of the stability and control derivatives, the Dryden Fligh Research Center (DFRC) developed a technique for extracting the derivatives from flight data. This technique is implemented by a set of FORTRAN computer programs that is based on a modified maximum likelihood estimator that uses the Newton-Raphson algorithm to perform the required minimization of the derivatives. Data was obtained with a PA-30, light twin-engine general aviation aircraft in zero, half, and full flap configuration in level unaccelerated flight with the landing gear retracted. The derivatives were plotted as functions of angle of attack using various graphical arrangements to show variations of wind tunnel and flight determined values at zero flap settings. Also, data was displayed to show the effects of flap deflection and thrust variation on the longitudinal stability derivatives. The angle of attack and angle of sideslip were measured. The dynamic pressure, velocity, and altitude were calculated, using a FORTRAN computer program, from the static and dynamic pressures. The control deflections of the stabilator, ailerons, and rudder also were recorded along with left throttle position, engine rpm, and manifold pressure.

Turley, D. R.↗
NASA NTRS1990

High resolution derivative spectra in remote sensing

The use of derivative spectra is an established technique in analytical chemistry for the elimination of background signals and for resolving overlapping spectral features. Application of this technique for tackling analogous problems such as interference from soil background reflectance in the remote sensing of vegetation or for resolving complex spectra of several target species within individual pixels in remote sensing is proposed. Methods for generating derivatives of high spectral resolution data are reviewed. Results of experiments to test the use of derivatives for monitoring chlorosis in vegetation show that derivative spectral indices are superior to conventional broad-band spectral indices such as the near-infrared/red reflectance ratio. Conventional broad-band indices are sensitive to both leaf cover as well as leaf color. New derivative spectral indices which were able to monitor chlorosis unambiguously were identified. Potential areas for the application of this technique in remote sensing are considered.

Demetriades-Shah, Tanvir H.↗
NASA NTRS1988

Design principles for an interactive program derivation system

The main design principles of an interactive program transformation system called FOCUS are outlined. Its important characteristics are its human-oriented deduction techniques based replacement, emphasis on small search spaces, and the use of a tree structure to organize program derivations. The tree structure presents to the user a static picture of the derivation process and promotes flexibility in the development of derivations. The system keeps track of dependencies between different parts of derivations, and records the derivation activity for later use in automatic replay.

Reddy, Uday S.↗
NASA NTRS1990

The 27-28 October 1986 FIRE IFO cirrus case study - Cloud parameter fields derived from satellite data

A cirrus parameter retrieval methodology and the results of its application over the cirrus Intensive Field Observation (IFO) area using data from the Geostationary Operational Environmental Satellite (GOES) taken during the FIRE cirrus case study days, October 27-28, 1986. An impirical cloud bidirectional reflectance model derived from another IFO analysis was combined with a theoretical ice crystal cloud albedo model to estimate visible cloud optical thickness, which was used to derive the cloud infrared emittance. Cloud altitude was adjusted based on the derived emittance and observed temperatures. The approach developed here produced a very reasonable picture of cirrus cloud fields. It was estimated that the cloud-top and cloud-center heights are derived with a precision of about 0.6 km, except in very broken cloud conditions. Cirrus cloud thicknesses were also estimated and it is found that the derived results are comparable to other case study observations.

Minnis, Patrick↗
NASA NTRS1992

On the Yakhot-Orszag renormalization group method for deriving turbulence statistics and models

An independent, comprehensive, critical review of the 'renormalization group' (RNG) theory of turbulence developed by Yakhot and Orszag (1986) is provided. Their basic theory for the Navier-Stokes equations is confirmed, and approximations in the scale removal procedure are discussed. The YO derivations of the velocity-derivative skewness and the transport equation for the energy dissipation rate are examined. An algebraic error in the derivation of the skewness is corrected. The corrected RNG skewness value of -0.59 is in agreement with experiments at moderate Reynolds numbers. Several problems are identified in the derivation of the energy dissipation rate equations which suggest that the derivation should be reformulated.

Smith, L. M.↗
NASA NTRS1993

Theoretical calculations on the electron absorption spectra of selected Polycyclic Aromatic Hydrocarbons (PAH) and derivatives

As a theoretical component of the joint effort with the laboratory of Dr. Lou Allamandola to search for potential candidates for interstellar organic carbon compound that are responsible for the visible diffuse interstellar absorption bands (DIB's), quantum mechanical calculations were performed on the electron absorption spectra of selected polycyclic aromatic hydrocarbons (PAH) and derivatives. In the completed project, 15 different species of naphthalene, its hydrogen abstraction and addition derivatives, and corresponding cations and anions were studied. Using semiempirical quantum mechanical method INDO/S, the ground electronic state of each species was evaluated with restricted Hartree-Fock scheme and limited configuration interaction. The lowest energy spin state for each species was used for electron absorption calculations. Results indicate that these calculations are accurate enough to reproduce the spectra of naphthalene cation and anion observed in neon matrix. The spectral pattern of the hydrogen abstraction and addition derivatives predicted based on these results indicate that the electron configuration of the pi orbitals of these species is the dominant determinant. A combined list of 19 absorptions calculated from 4500 A to 10,400 A were compiled and suggested as potential candidates that are relevant for the DIB's absorptions. Continued studies on pyrene and derivatives revealed the ground state symmetries and multiplicities of its neutral, anionic, and cationic species. Spectral calculations show that the cation (B(sub 3g)-2) and the anion (A(sub u)-2) are more likely to have low energy absorptions in the regions between 10 kK and 20 kK, similar to naphthalene. These absorptions, together with those to be determined from the hydrogen abstraction and addition derivatives of pyrene, can be used to provide additional candidates and suggest experimental work in the search for interstellar compounds that are responsible for DIB's.

Du, Ping↗
NASA NTRS1992

Multidisciplinary analysis and sensitivity derivatives for isolated helicopter rotors in hover

A new method is presented for using Navier-Stokes results in the system analysis and sensitivity derivative computations for a helicopter rotor in hover. The system coupling includes the interactions between rotor performance, rotor structural properties and aerodynamics (i.e., airfoil shape). Emphasis is placed on the use of high fidelity Navier-Stokes algorithms for the aerodynamic problem. The present formulation is chosen to reduce the number of sensitivity derivative equations and their dimensions as much as possible. In addition, an alternative adjoint formulation is presented which dramatically reduces the computational requirement for disciplines in which there may be a large number of design variables (e.g., aerodynamics). The theoretical method makes use of a combination of derivatives from each discipline; the computation of these derivatives has already been shown to be feasible. Sample computations for the aerodynamic-rotor model coupling and an associated sensitivity derivative are also presented.

Jones, Henry E.↗
NASA NTRS1993

Structural design utilizing updated, approximate sensitivity derivatives

A method to improve the computational efficiency of structural optimization algorithms is investigated. In this method, the calculations of 'exact' sensitivity derivatives of constraint functions are performed only at selected iterations during the optimization process. The sensitivity derivatives utilized within other iterations are approximate derivatives which are calculated using an inexpensive derivative update formula. Optimization results are presented for an analytic optimization problem (i.e., one having simple polynomial expressions for the objective and constraint functions) and for two structural optimization problems. The structural optimization results indicate that up to a factor of three improvement in computation time is possible when using the updated sensitivity derivatives.

Scotti, Stephen J.↗