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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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NASA NTRS2015

Pioneering Objectives and Activities on the Surface of Mars

Human Mars missions have been a topic of sustained interest within NASA, which continues to use its resources to examine many different mission objectives, trajectories, vehicles, and technologies, the combinations of which are often referred to as reference missions or architectures. The current investigative effort, known as the Evolvable Mars Campaign (EMC), is examining alternatives that can pioneer an extended human presence on Mars that is Earth independent. These alternatives involve combinations of all the factors just mentioned. This paper is focused on the subset of these factors involved with objectives and activities that take place on the surface of Mars. "Pioneering" is a useful phrase to encapsulate the current approach being used to address this situation - one of its primary definitions is "a person or group that originates or helps open up a new line of thought or activity or a new method or technical development". Thus, in this scenario, NASA would be embarking on a path to "pioneer" a suite of technologies and operations that will result in an Earth independent, extended stay capability for humans on Mars. This paper will describe (a) the concept of operation determined to be best suited for the initial emplacement, (b) the functional capabilities determined to be necessary for this emplacement, with representative examples of systems that could carry out these functional capabilities and one implementation example (i.e., delivery sequence) at a representative landing site, and will (c) discuss possible capabilities and operations during subsequent surface missions.

Toups, Larry↗
NASA NTRS2014

Oxidative Stress Responses to Simulated Spaceflight in Mineralized and Marrow Compartments of Bone and Associated Vasculature

Long-term spaceflight causes profound changes to the musculoskeletal system attributable to unloading and fluid shifts in microgravity. Future space explorations beyond the earth’s magnetosphere will expose astronauts to space radiation, which may cause additional skeletal deficits that are not yet fully understood. Our long-term goals are twofold: to define the mechanisms and risk of bone loss in the spaceflight environment and to facilitate the development of effective countermeasures if necessary. Our central hypothesis is that oxidative stress plays a key role in progressive bone loss and vascular dysfunction caused by spaceflight. In animal’s models, overproduction of free radicals is associated with increased bone resorption, lower bone formation, and decrements in bone mineral density and structure which can ultimately lead to skeletal fragility. Evidence in support of a possible causative role for oxidative stress in spaceflight-induced bone loss derive from knockout and transgenic mouse studies and the use of pharmacological interventions with known anti-oxidant properties. In our studies to simulate spaceflight, 16-wk old, male C56Bl/6J mice were assigned to one of four groups: hind limb unloading to simulate weightlessness (HU), normally loaded Controls (‘NL’) (sham irradiated, no hind limb unloading), irradiated at NASA Space Radiation Laboratory ‘IR’ with 1-2Gy of (600MeV/n) alone, or in combination with protons (0.5Gy Protons/0.5Gy 56Fe), (IR) or both hind limb unloaded and irradiated, ‘HU+IR’. Mice were exposed to radiation 3 days after initiating HU and tissues harvested were 1-14 days after initiating treatments for analyses. Results from our laboratories, which employ various biochemical, gene expression, functional, and transgenic animal model methods, implicate dynamic regulation of redox-related pathways by spaceflight-related environmental factors. As one example, we found that combined HU and radiation exposure caused oxidative damage in skeletal tissues (lipid peroxidation) of wildtype mice, whereas bone from transgenic mice that overexpress human catalase in mitochondria were protected. Interestingly, marrow cells grown under culture conditions that select for endothelial progenitor cells (EPC), showed that HU but not IR reduced EPC cell migration; in contrast HU and IR each inhibited growth of marrow-derived osteoblast progenitors. Taken together, these results indicate that unloading and ionizing elicit distinct effects on progenitor and mature cells of vascular and skeletal tissue, and that oxidative damage may contribute to skeletal and vascular deficits that may emerge during extended space travel.

Globus, R. K.↗
NASA NTRS1990

Technical aspects of a demonstration tape for three-dimensional sound displays

This document was developed to accompany an audio cassette that demonstrates work in three-dimensional auditory displays, developed at the Ames Research Center Aerospace Human Factors Division. It provides a text version of the audio material, and covers the theoretical and technical issues of spatial auditory displays in greater depth than on the cassette. The technical procedures used in the production of the audio demonstration are documented, including the methods for simulating rotorcraft radio communication, synthesizing auditory icons, and using the Convolvotron, a real-time spatialization device.

Begault, Durand R.↗
NASA NTRS2009

Extravehicular Activity Testing in Analog Environments: Evaluating the Effects of Center of Gravity and Environment on Human Performance

The EVA Physiology, Systems and Performance (EPSP) Project is performing tests in different analog environments to understand human performance during Extravehicular Activity (EVA) with the aim of developing more safe and efficient systems for lunar exploration missions and the Constellation Program. The project is characterizing human EVA performance in studies using several test beds, including the underwater NASA Extreme Environment Mission Operations (NEEMO) and Neutral Buoyancy Laboratory (NBL) facilities, JSC fs Partial Gravity Simulator (POGO), and the NASA Reduced Gravity Office (RGO) parabolic flight aircraft. Using these varied testing environments, NASA can gain a more complete understanding of human performance issues related to EVA and the limitations of each testing environment. Tests are focused on identifying and understanding the EVA system factors that affect human performance such as center of gravity (CG), inertial mass, ground reaction forces (GRF), suit weight, and suit pressure. The test results will lead to the development of lunar EVA systems operations concepts and design requirements that optimize human performance and exploration capabilities. METHODS: Tests were conducted in the NBL and during NEEMO missions in the NOAA Aquarius Habitat. A reconfigurable back pack with repositionable mass was used to simulate Perfect, Low, Forward, High, Aft and NASA Baseline CG locations. Subjects performed simulated exploration tasks that included ambulation, kneel and recovery, rock pick-up, and shoveling. Testing using POGO, that simulates partial gravity via pneumatic weight offload system and a similar reconfigurable rig, is underway for a subset of the same tasks. Additionally, test trials are being performed on the RGO parabolic flight aircraft. Subject performance was assessed using a modified Cooper-Harper scale to assess operator compensation required to achieve desired performance. All CG locations are based on the assumption of a standardized 6 ft 180 lb subject. RESULTS: The modified Cooper-Harper Scale assesses desired task performance described as performance in a reduced gravity environment as compared to a 1G environment. Modified Cooper-Harper ratings of . 3 indicate no improvements are needed, ratings of 4-6 indicate improvements are desirable, and ratings . 7 indicate improvements are mandatory. DISCUSSION: Differences were noted in suited CH results based on environment at the same CG and suit pressure. Additionally, results suggest that CG location affects unsuited human performance. Subjects preferred locations near their natural CG over those that are high, aft, or a combination of high and aft. Further testing and analyses are planned to compare these unsuited results to suited performance.

Gernhardt, M.L.↗
NASA NTRS2005

Tissue Engineering Using Transfected Growth-Factor Genes

A method of growing bioengineered tissues includes, as a major component, the use of mammalian cells that have been transfected with genes for secretion of regulator and growth-factor substances. In a typical application, one either seeds the cells onto an artificial matrix made of a synthetic or natural biocompatible material, or else one cultures the cells until they secrete a desired amount of an extracellular matrix. If such a bioengineered tissue construct is to be used for surgical replacement of injured tissue, then the cells should preferably be the patient s own cells or, if not, at least cells matched to the patient s cells according to a human-leucocyteantigen (HLA) test. The bioengineered tissue construct is typically implanted in the patient's injured natural tissue, wherein the growth-factor genes enhance metabolic functions that promote the in vitro development of functional tissue constructs and their integration with native tissues. If the matrix is biodegradable, then one of the results of metabolism could be absorption of the matrix and replacement of the matrix with tissue formed at least partly by the transfected cells. The method was developed for articular chondrocytes but can (at least in principle) be extended to a variety of cell types and biocompatible matrix materials, including ones that have been exploited in prior tissue-engineering methods. Examples of cell types include chondrocytes, hepatocytes, islet cells, nerve cells, muscle cells, other organ cells, bone- and cartilage-forming cells, epithelial and endothelial cells, connective- tissue stem cells, mesodermal stem cells, and cells of the liver and the pancreas. Cells can be obtained from cell-line cultures, biopsies, and tissue banks. Genes, molecules, or nucleic acids that secrete factors that influence the growth of cells, the production of extracellular matrix material, and other cell functions can be inserted in cells by any of a variety of standard transfection techniques.

Madry, Henning↗
NASA NTRS1987

NAECON 87; Proceedings of the IEEE National Aerospace and Electronics Conference, Dayton, OH, May 18-22, 1987. Volumes 1, 2, 3, & 4

The present conference discusses topics in VLSI components and their packaging, signal processing, uses of cartographic data, data transmission, advanced avionics architectures, fiber-optics, information control and display, image processing, airborne radar and fire control, navigation, air data, Kalman filtering, power generation and control, spacecraft power structures, aircraft flying qualities, flight management, fault-tolerant computer architectures, actuation technologies, self-repairing flight control system technology, multivariable control, stability and control methods, and AFTI/F-16 flight test reports. Also discussed are the ADA/JOVIAL language and its applications, software acquisition and testing, advanced software concepts, software management, computer graphics and visual systems softwear, ADA in embedded avionics, 16- and 32-bit architectures, voice interaction applications, human/machine systems analysis, human factors and AI, mental workloads and displays, pilot acceleration protection research, communications system technology, space communications, reliability and maintainability, managerial techniques, engineering management, EM compatibility and nuclear hardening, expert systems, AI language/knowledge representation, expert system implementation, machine vision/optical processing, and advanced AI concepts and architectures.

Avionics↗
NASA NTRS1995

Design and Testing of an Automated System using Thermochromatic Liquid Crystals to Determine Local Heat Transfer Coefficients for an Impinging Jet

Using thermochromatic liquid crystal to measure surface temperature, an automated transient method with time-varying free-stream temperature is developed to determine local heat transfer coefficients. By allowing the free-stream temperature to vary with time, the need for complicated mechanical components to achieve a step temperature change is eliminated, and by using the thermochromatic liquid crystals as temperature indicators, the labor intensive task of installing many thermocouples is omitted. Bias associated with human perception of the transition of the thermochromatic liquid crystal is eliminated by using a high speed digital camera and a computer. The method is validated by comparisons with results obtained by the steady-state method for a circular Jet impinging on a flat plate. Several factors affecting the accuracy of the method are evaluated.

Tan, Benjamin↗
NASA NTRS2010

A Technique for the Assessment of Flight Operability Characteristics of Human Rated Spacecraft

In support of new human rated spacecraft development programs, the Mission Operations Directorate at NASA Johnson Space Center has implemented a formal method for the assessment of spacecraft operability. This "Spacecraft Flight Operability Assessment Scale" defines six key themes of flight operability, with guiding principles and goals stated for each factor. A standardized rating technique provides feedback that is useful to the operations, design and program management communities. Applicability of this concept across the program structure and life cycle is addressed. Examples of operationally desirable and undesirable spacecraft design characteristics are provided, as is a sample of the assessment scale product.

Crocker, Alan↗
NASA NTRS2007

Modeling Malaria Transmission in Thailand and Indonesia

Malaria Modeling and Surveillance is a project in the NASA Applied Sciences Public Health Applications Program. The main objectives of this project are: 1) identification of the potential breeding sites for major vector species: 2) implementation of a malaria transmission model to identify they key factors that sustain or intensify malaria transmission; and 3) implementation of a risk algorithm to predict the occurrence of malaria and its transmission intensity. Remote sensing and GIs are the essential elements of this project. The NASA Earth science data sets used in this project include AVHRR Pathfinder, TRMM, MODIS, NSIPP and SIESIP. Textural-contextual classifications are used to identify small larval habitats. Neural network methods are used to model malaria cases as a function of precipitation, temperatures, humidity and vegetation. Hindcastings based on these environmental parameters have shown good agreement to epidemiological records. Examples for spatio-temporal modeling of malaria transmissions in Southeast Asia are given. Discrete event simulations were used for modeling the detailed interactions among the vector life cycle, sporogonic cycle and human infection cycle, under the explicit influences of selected extrinsic and intrinsic factors. The output of the model includes the individual infection status and the quantities normally observed in field studies, such as mosquito biting rates, sporozoite infection rates, gametocyte prevalence and incidence. Results are in good agreement with mosquito vector and human malaria data acquired by Coleman et al. over 4.5 years in Kong Mong Tha, a remote village in western Thailand. Application of our models is not restricted to Southeast Asia. The model and techniques are equally applicable to other regions of the world, when appropriate epidemiological and vector ecological parameters are used as input.

Kiang, Richard↗
NASA NTRS1998

Evaluation of pGL1-TNF-alpha therapy in combination with radiation

Long-term control of high-grade brain tumors is rarely achieved with current therapeutic regimens. In this study a new plasmid-based human tumor necrosis factor-alpha (TNF-alpha) expression vector was synthesized (pGL1-TNF-alpha) and evaluated together with radiation in the aggressive, rapidly growing C6 rat glioma model. pGL1-TNF-alpha was successfully transfected into C6 cells in vitro using a cationic polyamine method. Expression was detected up to 7 days and averaged 0.4 ng of TNF-alpha in the culture medium from 1x10(5) cells. The expressed protein was biologically functional, as evidenced by growth inhibition of L929, a TNF-alpha-susceptible cell line. Using fluorescence-labeled monoclonal antibodies and laser scanning cytometry, we confirmed that both the P55 and P75 receptors for TNF-alpha were present on the C6 cell membrane. However, the receptors were present at low density and P55 was expressed more than the P75 receptor. These findings were in contrast to results obtained with TNF-alpha-susceptible L929 cells. Tests in athymic mice showed that pGL1-TNF-alpha administered intratumorally 16-18 h before radiation (each modality given three times) significantly inhibited C6 tumor progression (P<0.05). This effect was more than additive, because pGL1-TNF-alpha alone did not slow tumor growth and radiation alone had little effect on tumor growth. These results indicate that pGL1-TNF-alpha has potential to augment the antitumor effects of radiation against a tumor type that is virtually incurable.

Non-NASA Center↗
NASA NTRS2016

Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders: Evidence Report

In April 2010, President Obama declared a space pioneering goal for the United States in general and NASA in particular. "Fifty years after the creation of NASA, our goal is no longer just a destination to reach. Our goal is the capacity for people to work and learn and operate and live safely beyond the Earth for extended periods of time, ultimately in ways that are more sustainable and even indefinite." Thus NASA's Strategic Objective 1.1 emerged as "expand human presence into the solar system and to the surface of Mars to advance exploration, science, innovation, benefits to humanity, and international collaboration" (NASA 2015b). Any space flight, be it of long or short duration, occurs in an extreme environment that has unique stressors. Even with excellent selection methods, the potential for behavioral problems among space flight crews remain a threat to mission success. Assessment of factors that are related to behavioral health can help minimize the chances of distress and, thus, reduce the likelihood of adverse cognitive or behavioral conditions and psychiatric disorders arising within a crew. Similarly, countermeasures that focus on prevention and treatment can mitigate the cognitive or behavioral conditions that, should they arise, would impact mission success. Given the general consensus that longer duration, isolation, and confined missions have a greater risk for behavioral health ensuring crew behavioral health over the long term is essential. Risk, which within the context of this report is assessed with respect to behavioral health and performance, is addressed to deter development of cognitive and behavioral degradations or psychiatric conditions in space flight and analog populations, and to monitor, detect, and treat early risk factors, predictors and other contributing factors. Based on space flight and analog evidence, the average incidence rate of an adverse behavioral health event occurring during a space mission is relatively low for the current conditions. While mood and anxiety disturbances have occurred, no behavioral emergencies have been reported to date in space flight. Anecdotal and empirical evidence indicate that the likelihood of an adverse cognitive or behavioral condition or psychiatric disorder occurring greatly increases with the length of a mission. Further, while cognitive, behavioral, or psychiatric conditions might not immediately and directly threaten mission success, such conditions can, and do, adversely impact individual and crew health, welfare, and performance.

Slack, Kelley J.↗
NASA NTRS2019

Space Research Project Management Can Benefit from Engineering Technology Selection Methods

Many engineering methods have been developed to help management select technology for a system design or further research. The simplest way to compare technologies is to use a checklist containing all the more or less important selection criteria, so that nothing is overlooked. The criteria usually include cost, safety, reliability and maintainability, and potential problems such as noise generation and microgravity sensitivity. The next step typically is to weight and score all the criteria. The process of weighting and scoring is helpful in bringing out different priorities and reaching a shared point of view. Group technology selection methods are designed to highlight initial disagreements and produce a shared consensus. Often a frank discussion led by management rather than decision analysts can be more effective. The final selection depends on management and engineering judgment and may include programmatic and organizational factors that are beyond the engineering checklist. The objective of engineering technology selection methods is to provide engineering information to assist management in making sound decisions. Project management and technology selection are assumed to use rational engineering analytic methods, but they often do not. The reason is that human insight, intuition, and “gut feel,” rather than logic, more frequently determine our decisions. Project selection and management are strongly influenced by nonrational psychological influences, which can produce unjustified confidence and determination. Nevertheless, there is a strong need for space projects to do rational project analysis and selection. Demonstrating a rational spirit is necessary for a scientific and technical organization. Professional ethics at its best requires an open, honest, and fair process, without damaging politics. Rational analysis can help improve good projects and avoid selecting bad ones. A sanity check using rational analysis guided by a checklist can help avoid egregious and damaging errors.

Jones, Harry W.↗
NASA NTRS2020

University of Maryland Minimum Crew Cabin Studies ENAE484 X-Hab Final Report

With renewed interest in human spaceflight, and the astronomically high cost to send things into space, NASA is looking into methods for minimizing all aspects of crewed flight. While maintaining a crew of at least two to four people, there are considerations into duration, habitat size, habitat orientation, and many other factors to try and get the most science, safely, for the least amount of money. From these constraints, the class' project was organized. The topic of "Minimum Crew Cabin Sizing" was chosen, with a plan to do experimentation to verify or update some of the volumetric models for various activities. The actual crew cabin itself is something that can easily alter the mass, cost, and development time. In trying to quantify how small is too small { or what can be made smaller { programs can save money, time, and mass with an appropriately sized minimum volume habitat.

David Lee Akin↗
NASA NTRS2021

Guidance and Lessons Learned from COVID-19 for Human-Subjects Research

The goal of this effort was to identify innovative strategies, approaches, and methods that have enabled researchers to continue doing meaningful human subjects research during the COVID-19 pandemic. Many organizations and recent literature primarily focus on efforts for future research in a post-COVID environment. Additionally, there have been no systematic efforts across the agency or broader human factors community to coordinate or share strategies. Therefore, the focus was on acquiring knowledge gained by researchers from experiences during COVID that could be valuable to continue human-subjects research under existing restrictions.

Coronavirus Disease 2019↗
NASA NTRSDate not supplied

Crowd Sourcing Medical Data Collection Using Medical Students

OBJECTIVE We undertook an upgrade of the Evidence Library database of NASA HRP’s Integrated Medical Model, assessing 120 medical conditions which integrate with a novel probabilistic risk assessment (IMPACT) tool of medical risk and resource utilization for long duration exploration human spaceflight. This data collection process included a selection of these conditions crowd sourced over one year via three 4-week medical student electives at the University of Colorado School of Medicine (IDPT 8059 Space Medicine: Human Spaceflight Factors & Medical Risk Assessment). Students undertook a rapid systematic review of each medical condition, under close preceptors with backgrounds in clinical medicine, library science, epidemiology, biostatistics, and evidence-based medicine. As part of the elective, students also received instruction in core space medicine concepts, evidence based medicine and problem based learning sessions as a flight surgeon supporting a simulated Mars mission. METHODS The list of 120 medical conditions includes both common, terrestrial illness/injury (epistaxis, diverticulitis) as well as spaceflight-specific ones (space adaptation conditions, EVA-related injuries). A rapid systematic review process was developed that would allow students to find the data for determining disease incidence/prevalence, return to definitive care (often a surrogate such as hospitalization rates), loss of crew life, and treatment duration. Each data point required a tailored, specialized search process using different databases and corresponding specialized search filters. Databases were selected on their ability to provide high quality literature in an efficient manner and prioritized by their ability to provide graded evidence via a set rubrics specific to human spaceflight. Students were responsible for performing all literature searches and identifying the highest quality available evidence for each data point. Completed student data sheets underwent initial review by faculty preceptors followed by a secondary editing review by the ExMC Clinical Science Team. RESULTS Over the course of three electives, approximately 105 medical conditions were researched by students using spreadsheets with pre-crafted search strategies. Overall, this process was successful in allowing students to perform the preponderance of work to update incidence, treatment duration, return to definitive care, and loss of crew life data points. Students were successful in running searches, identifying the necessary data points within the literature, and determining the types of terrestrial data that most aligns with the astronaut population for successful completion of their tasks. Limitations included variable student experience with search methodologies [PubMed], differing values of evidence grading [best practice evidence based medicine vs. relevant to spaceflight], and students’ unfamiliarity with spaceflight specific conditions. CONCLUSION Finding the relevant literature for medical conditions in spaceflight within terrestrial databases in a systematic method is time consuming and not intuitive. However, the stepwise process that balanced sensitivity with specificity allowed for students to be highly successful in a short amount of time. Additionally, as the process was refined over the course of three electives, preceptors were better able to anticipate where students were likely to encounter barriers, which allowed the course to be adjusted to account for certain data points needing more time for completion. This replicable process may be an efficient way to accomplish rapid systematic reviews for a large volume of data in a short amount of time.

J Lemery↗
NASA NTRSDate not supplied

Effects of Autonomous sUAS Separation Methods on Subjective Workload, Situation Awareness, and Trust

The Unmanned Aircraft System (UAS) Traffic Management (UTM) concept was designed to support autonomous small UAS operations at a large-scale and without direct human intervention. However, human-autonomy interactions will be impacted by situation awareness, workload, and trust in the autonomy. Method: Nine participants monitored live small UAS operations in a representative UTM system during a series of traffic conflict scenarios and then provided subjective responses regarding situation awareness, workload, and trust in the autonomous separation method. The study employed a 3 (Separation Method: Autonomous Sense and Avoid, Geofence, Manual) × 2 (Incursion: High, Medium) within subjects design. Results: Situation awareness ratings for both autonomous separation methods were significantly lower than the manual condition. An interaction indicated differential workload ratings for the Autonomous Sense and Avoid separation ratings. Trust ratings significantly dropped when the Geofencing separation method failed. Conclusion: Subjective responses of remote operators in the UTM system are affected by the vehicle separation methods. Operators’ understanding of decisions made by the autonomous systems onboard the vehicle likely influence this effect

UAS↗
NASA NTRS1991

Human factors considerations for training astronauts to function effectively in multiple environments

This paper reviews some of the basic issues involved in training individuals to function appropriately under the several conditions that comprise the aerospace environment. The topic of transfer of training is examined in some detail, and the use of high-fidelity simulators in various training programs is discussed. Both current and classical techniques used to train astronauts are noted, and some relatively new and innovative training techniques and methods are described. Particularly, the paper discusses an important aspect of functioning appropriately in a given environment that is based on how well the operator calibrates his motor activity for that specific environment. The role of motor-sensory feedback for the acquisition of motor skills is discussed in the context of training.

Cohen, Malcolm M.↗
NASA NTRS2007

Synthesis from Design Requirements of a Hybrid System for Transport Aircraft Longitudinal Control

Volume I of this report presents a new method for synthesizing hybrid systems directly from design requirements, and applies the method to design of a hybrid system for longitudinal control of transport aircraft. The resulting system satisfies general requirement for safety and effectiveness specified a priori, enabling formal validation to be achieved. Volume II contains seven appendices intended to make the report accessible to readers with backgrounds in human factors, fli ght dynamics and control. and formal logic. Major design goals are (1) system desi g n integrity based on proof of correctness at the design level, (2), significant simplification and cost reduction in system development and certification, and (3) improved operational efficiency, with significant alleviation of human-factors problems encountered by pilots in current transport aircraft. This report provides for the first time a firm technical basis for criteria governing design and certification of avionic systems for transport aircraft. It should be of primary interest to designers of next-generation avionic systems.

Hynes, Charles S.↗