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NASA NTRS1998

Reliability Modeling Methodology for Independent Approaches on Parallel Runways Safety Analysis

This document is an adjunct to the final report An Integrated Safety Analysis Methodology for Emerging Air Transport Technologies. That report presents the results of our analysis of the problem of simultaneous but independent, approaches of two aircraft on parallel runways (independent approaches on parallel runways, or IAPR). This introductory chapter presents a brief overview and perspective of approaches and methodologies for performing safety analyses for complex systems. Ensuing chapter provide the technical details that underlie the approach that we have taken in performing the safety analysis for the IAPR concept.

Babcock, P.↗

NASA NTRS1998

A 2-D Interface Element for Coupled Analysis of Independently Modeled 3-D Finite Element Subdomains

Over the past few years, the development of the interface technology has provided an analysis framework for embedding detailed finite element models within finite element models which are less refined. This development has enabled the use of cascading substructure domains without the constraint of coincident nodes along substructure boundaries. The approach used for the interface element is based on an alternate variational principle often used in deriving hybrid finite elements. The resulting system of equations exhibits a high degree of sparsity but gives rise to a non-positive definite system which causes difficulties with many of the equation solvers in general-purpose finite element codes. Hence the global system of equations is generally solved using, a decomposition procedure with pivoting. The research reported to-date for the interface element includes the one-dimensional line interface element and two-dimensional surface interface element. Several large-scale simulations, including geometrically nonlinear problems, have been reported using the one-dimensional interface element technology; however, only limited applications are available for the surface interface element. In the applications reported to-date, the geometry of the interfaced domains exactly match each other even though the spatial discretization within each domain may be different. As such, the spatial modeling of each domain, the interface elements and the assembled system is still laborious. The present research is focused on developing a rapid modeling procedure based on a parametric interface representation of independently defined subdomains which are also independently discretized.

Kandil, Osama A.↗

NASA NTRS2000

]Space Shuttle Independent Assessment Team

The Shuttle program is one of the most complex engineering activities undertaken anywhere in the world at the present time. The Space Shuttle Independent Assessment Team (SIAT) was chartered in September 1999 by NASA to provide an independent review of the Space Shuttle sub-systems and maintenance practices. During the period from October through December 1999, the team led by Dr. McDonald and comprised of NASA, contractor, and DOD experts reviewed NASA practices, Space Shuffle anomalies, as well as civilian and military aerospace experience. In performing the review, much of a very positive nature was observed by the SIAT, not the least of which was the skill and dedication of the workforce. It is in the unfortunate nature of this type of review that the very positive elements are either not mentioned or dwelt upon. This very complex program has undergone a massive change in structure in the last few years with the transition to a slimmed down, contractor-run operation, the Shuttle Flight Operations Contract (SFOC). This has been accomplished with significant cost savings and without a major incident. This report has identified significant problems that must be addressed to maintain an effective program. These problems are described in each of the Issues, Findings or Observations summarized, and unless noted, appear to be systemic in nature and not confined to any one Shuttle sub-system or element. Specifics are given in the body of the report, along with recommendations to improve the present systems.

Source record↗

NASA NTRS2000

Mars Program Independent Assessment Team Report

The Mars Climate Orbiter failed to achieve Mars orbit on September 23, 1999. On December 3, 1999, Mars Polar Lander and two Deep Space 2 microprobes failed. As a result, the NASA Administrator established the Mars Program Independent Assessment Team (MPIAT) with the following charter: 1) Review and analyze successes and failures of recent Mars and Deep Space Missions which include: a) Mars Global Surveyor, b) Mars Climate Orbiter, c) Pathfinder, d) Mars Polar Lander, e) Deep Space 1, and f) Deep Space 2; 2) Examine the relationship between and among, NASA Jet Propulsion Laboratory (JPL), California Institute of Technology (Caltech), NASA Headquarters, and industry partners; 3) Assess effectiveness of involvement of scientists; 4) Identify lessons learned from successes and failures; 5) Review revised Mars Surveyor Program to assure lessons learned are utilized; 6) Oversee Mars Polar Lander and Deep Space 2 failure reviews; and 7) Complete by March 15, 2000. In-depth reviews were conducted at NASA Headquarters, JPL, and Lockheed Martin Astronautics (LMA). Structured reviews, informal sessions with numerous Mars Program participants, and extensive debate and discussion within the MPIAT establish the basis for this report. The review process began on January 7, 2000, and concluded with a briefing to the NASA Administrator on March 14, 2000. This report represents the integrated views of the members of the MPIAT who are identified in the appendix. In total, three related reports have been produced: a summary report, this report entitled "Mars Program Independent Assessment Team Report," and the "Report on the Loss of the Mars Polar Lander and Deep Space 2 Missions".

Young, Thomas↗

NASA NTRS2000

Towards Solving the Mixing Problem in the Decomposition of Geophysical Time Series by Independent Component Analysis

The use of the Principal Component Analysis technique for the analysis of geophysical time series has been questioned in particular for its tendency to extract components that mix several physical phenomena even when the signal is just their linear sum. We demonstrate with a data simulation experiment that the Independent Component Analysis, a recently developed technique, is able to solve this problem. This new technique requires the statistical independence of components, a stronger constraint, that uses higher-order statistics, instead of the classical decorrelation a weaker constraint, that uses only second-order statistics. Furthermore, ICA does not require additional a priori information such as the localization constraint used in Rotational Techniques.

Aires, Filipe↗

NASA NTRS2002

The Relative Humidity of the Atmosphere in the Encasements Containing the Declaration of Independence, the US Constitution (Pages 1 and 4), and the Bill of Rights

In 1951, the four pages of the US Constitution, the Letter of Transmittal, the Bill of Rights and the Declaration of Independence, collectively called the 'Charters of Freedom,' were hermetically sealed individually in glass encasements. The atmosphere in the encasements consisted of a mixture of helium with water vapor at a relative humidity between 25 and 35% at room temperature. In 1998, Margaret Kelly of the National Archives and Records Administration (NARA), contacted Dr. Joel S. Levine at NASA Langley Research Center (LaRC) to request assistance in determining the chemical composition of the atmosphere inside the encasements. Several different Langley learns were assembled to address that request. each using a different measurement technique. This report describes the method and results of one team's relative humidity measurements on encasements containing pages 1 and 4 of the US Constitution, the Bill of Rights, and the Declaration of Independence performed at NARA, College Park. Maryland, on July 23, 2001.

West, James W.↗

NASA NTRS2003

Transition-Independent Decentralized Markov Decision Processes

There has been substantial progress with formal models for sequential decision making by individual agents using the Markov decision process (MDP). However, similar treatment of multi-agent systems is lacking. A recent complexity result, showing that solving decentralized MDPs is NEXP-hard, provides a partial explanation. To overcome this complexity barrier, we identify a general class of transition-independent decentralized MDPs that is widely applicable. The class consists of independent collaborating agents that are tied up by a global reward function that depends on both of their histories. We present a novel algorithm for solving this class of problems and examine its properties. The result is the first effective technique to solve optimally a class of decentralized MDPs. This lays the foundation for further work in this area on both exact and approximate solutions.

Becker, Raphen↗

NASA NTRS2002

Independent Confirmation of the Pioneer 10 Anomalous Acceleration

I perform an independent analysis of radio Doppler tracking data from the Pioneer 10 spacecraft for the time period 1987-1994. All of the tracking data were taken from public archive sources, and the analysis tools were developed independently by myself. I confirm that an apparent anomalous acceleration is acting on the Pioneer 10 spacecraft, which is not accounted for by present physical models of spacecraft navigation. My best fit value for the acceleration, including corrections for systematic biases and uncertainties, is (8.60 plus or minus 1.34) x 10(exp -8) centimeters per second, directed towards the Sun. This value compares favorably to previous results. I examine the robustness of my result to various perturbations of the analysis method, and find agreement to within plus or minus 5%. The anomalous acceleration is reasonably constant with time, with a characteristic variation time scale of greater than 70 yr. Such a variation timescale is still too short to rule out on-board thermal radiation effects, based on this particular Pioneer 10 data set.

Markwardt, Craig B.↗

NASA NTRS2003

Grid-Independent Large-Eddy Simulation in Turbulent Channel Flow using Three-Dimensional Explicit Filtering

In this paper, turbulence-closure models are evaluated using the 'true' LES approach in turbulent channel flow. The study is an extension of the work presented by Gullbrand (2001), where fourth-order commutative filter functions are applied in three dimensions in a fourth-order finite-difference code. The true LES solution is the grid-independent solution to the filtered governing equations. The solution is obtained by keeping the filter width constant while the computational grid is refined. As the grid is refined, the solution converges towards the true LES solution. The true LES solution will depend on the filter width used, but will be independent of the grid resolution. In traditional LES, because the filter is implicit and directly connected to the grid spacing, the solution converges towards a direct numerical simulation (DNS) as the grid is refined, and not towards the solution of the filtered Navier-Stokes equations. The effect of turbulence-closure models is therefore difficult to determine in traditional LES because, as the grid is refined, more turbulence length scales are resolved and less influence from the models is expected. In contrast, in the true LES formulation, the explicit filter eliminates all scales that are smaller than the filter cutoff, regardless of the grid resolution. This ensures that the resolved length-scales do not vary as the grid resolution is changed. In true LES, the cell size must be smaller than or equal to the cutoff length scale of the filter function. The turbulence-closure models investigated are the dynamic Smagorinsky model (DSM), the dynamic mixed model (DMM), and the dynamic reconstruction model (DRM). These turbulence models were previously studied using two-dimensional explicit filtering in turbulent channel flow by Gullbrand & Chow (2002). The DSM by Germano et al. (1991) is used as the USFS model in all the simulations. This enables evaluation of different reconstruction models for the RSFS stresses. The DMM consists of the scale-similarity model (SSM) by Bardina et al. (1983), which is an RSFS model, in linear combination with the DSM. In the DRM, the RSFS stresses are modeled by using an estimate of the unfiltered velocity in the unclosed term, while the USFS stresses are modeled by the DSM. The DSM and the DMM are two commonly used turbulence-closure models, while the DRM is a more recent model.

Gullbrand, Jessica↗

NASA NTRS2003

Independent Testing of JWST Detector Prototypes

The Independent Detector Testing Laboratory (IDTL) is jointly operated by the Space Telescope Science Institute (STScI) and the Johns Hopkins University (MU), and is assisting the James Webb Space Telescope (JWST) mission in choosing and operating the best near-infrared detectors under a NASA Grant. The JWST is the centerpiece of the NASA Office of Space Science theme, the Astronomical Search for Origins, and the highest priority astronomy project for the next decade, according to the National Academy of Science. JWST will need to have the sensitivity to see the first light in the Universe to determine how galaxies formed in the web of dark matter that existed when the Universe was in its infancy (z approx. 10 - 20). To achieve this goal, the JWST Project must pursue an aggressive technology program and advance infrared detectors to performance levels beyond what is now possible. As part of this program, NASA has selected the IDTL to verify comparative performance between prototype JWST detectors developed by Rockwell Scientific (HgCdTe) and Raytheon (InSb). The IDTL is charged with obtaining an independent assessment of the ability of these two competing technologies to achieve the demanding specifications of the JWST program within the 0.6 - 5 approx. mum bandpass and in an ultra-low background (less than 0.01 e'/s/pixel) environment. We describe results from the JWST Detector Characterization Project that is being performed in the IDTL. In this project, we are measuring first-order detector parameters, i.e. dark current, read noise, QE, intra-pixel sensitivity, linearity, as functions of temperature, well size, and operational mode.

Figer, D. F.↗

NASA NTRS2002

An ATM-independent S-phase checkpoint response involves CHK1 pathway

After exposure to genotoxic stress, proliferating cells actively slow down the DNA replication through a S-phase checkpoint to provide time for repair. We report that in addition to the ataxia-telangiectasia mutated (ATM)-dependent pathway that controls the fast response, there is an ATM-independent pathway that controls the slow response to regulate the S-phase checkpoint after ionizing radiation in mammalian cells. The slow response of S-phase checkpoint, which is resistant to wortmannin, sensitive to caffeine and UCN-01, and related to cyclin-dependent kinase phosphorylation, is much stronger in CHK1 overexpressed cells, and it could be abolished by Chk1 antisense oligonucleotides. These results provide evidence that the ATM-independent slow response of S-phase checkpoint involves CHK1 pathway.

Non-NASA Center↗

NASA NTRS2001

YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components

YC-1 [3-(5'-hydroxymethyl-2'furyl)-1-benzyl indazole] is an allosteric activator of soluble guanylyl cyclase (sGC). YC-1 increases the catalytic rate of the enzyme and sensitizes the enzyme toward its gaseous activators nitric oxide or carbon monoxide. In other studies the administration of YC-1 to experimental animals resulted in the inhibition of the platelet-rich thrombosis and a decrease of the mean arterial pressure, which correlated with increased cGMP levels. However, details of YC-1 interaction with sGC and enzyme activation are incomplete. Although evidence in the literature indicates that YC-1 activation of sGC is strictly heme-dependent, this report presents evidence for both heme-dependent and heme-independent activation of sGC by YC-1. The oxidation of the sGC heme by 1H-(1,2,4)oxadiazole(4,3-a)quinoxalin-1-one completely inhibited the response to NO, but only partially attenuated activation by YC-1. We also observed activation by YC-1 of a mutant sGC, which lacks heme. These findings indicate that YC-1 activation of sGC can occur independently of heme, but that activation is substantially increased when the heme moiety is present in the enzyme.

NASA Discipline Cardiopulmonary↗

NASA NTRS2000

Androgen and taxol cause cell type-specific alterations of centrosome and DNA organization in androgen-responsive LNCaP and androgen-independent DU145 prostate cancer cells

We investigated the effects of androgen and taxol on the androgen-responsive LNCaP and androgen-independent DU145 prostate cancer cell lines. Cells were treated for 48 and 72 h with 0.05-1 nM of the synthetic androgen R1881 and with 100 nM taxol. Treatment of LNCaP cells with 0.05 nM R1881 led to increased cell proliferation, whereas treatment with 1 nM R1881 resulted in inhibited cell division, DNA cycle arrest, and altered centrosome organization. After treatment with 1 nM R1881, chromatin became clustered, nuclear envelopes convoluted, and mitochondria accumulated around the nucleus. Immunofluorescence microscopy with antibodies to centrosomes showed altered centrosome structure. Although centrosomes were closely associated with the nucleus in untreated cells, they dispersed into the cytoplasm after treatment with 1 nM R1881. Microtubules were only faintly detected in 1 nM R1881-treated LNCaP cells. The effects of taxol included microtubule bundling and altered mitochondria morphology, but not DNA organization. As expected, the androgen-independent prostate cancer cell line DU145 was not affected by R1881. Treatment with taxol resulted in bundling of microtubules in both cell lines. Additional taxol effects were seen in DU145 cells with micronucleation of DNA, an indication of apoptosis. Simultaneous treatment with R1881 and taxol had no additional effects on LNCaP or DU145 cells. These results suggest that LNCaP and DU145 prostate cancer cells show differences not only in androgen responsiveness but in sensitivity to taxol as well. Copyright 2000 Wiley-Liss, Inc.

NASA Program Fundamental Space Biology↗

NASA NTRS2000

Parabolic flight reveals independent binocular control of otolith-induced eye torsion

To examine otolith-governed ocular torsion in hyper- and hypogravity, eight subjects, including two astronauts, underwent parabolic flight while seated upright with head fixed. A mask fitted with two video cameras provided synchronized images of both eyes at a rate of 25/sec during 15 parabolas, the individual parabolas separated by a few minutes of level 1 G flight. Three main findings emerged: 1) After the first parabola, most subjects showed differential torsional offset of the two eyes in the 1 G portions between parabolas, compared to the conjugate baseline position of the eyes prior to the first parabola. 2) Changes in binocular torsion in the 0 G and 1.8 G portions of parabolic flight revealed in most subjects systematic reversal of direction. The reversal was consistent within, but not across subjects. 3) Disconjugacy defined as the moment-to-moment difference in the movements of the two eyes, and evaluated without the contribution of the differential offset, found two subjects with relatively high disconjugacy scores, and the remaining six with low scores. On the basis of prior studies (9, 20), we would predict the first two would be subject to SMS, the remainder not. The two astronauts, who did not have SMS on their space missions, fell into the low scoring group. We propose that the disconjugacies may be due to intrinsic asymmetries in the otolith receptors on the two sides of the head, which appear to be independently linked to the extraocular muscles of the two eyes, a phenomenon masked in normal 1 G states by adaptation. The apparently independent control of the two sides cannot be detected by the simpler and more common monocular studies.

Non-NASA Center↗

NASA NTRS2004

Independent Testing of JWST Detector Prototypes

The Independent Detector Testing Laboratory (IDTL) is jointly operated by the Space Telescope Science Institute (STScI) and the Johns Hopkins University (JHU), and is assisting the James Webb Space Telescope (JWST) mission in choosing and operating the best near-infrared detectors. The JWST is the centerpiece of the NASA Office of Space Science theme, the Astronomical Search for Origins, and the highest priority astronomy project for the next decade, according to the National Academy of Science. JWST will need to have the sensitivity to see the first light in the Universe to determine how galaxies formed in the web of dark matter that existed when the Universe was in its infancy (z is approximately 10-20). To achieve this goal, the JWST Project must pursue an aggressive technology program and advance infrared detectors to performance levels beyond what is now possible. As part of this program, NASA has selected the IDTL to verify comparative performance between prototype JWST detectors developed by Rockwell Scientific (HgCdTe) and Raytheon (InSb). The IDTL is charged with obtaining an independent assessment of the ability of these two competing technologies to achieve the demanding specifications of the JWST program within the 0.6-5 micron bandpass and in an ultra-low background (less than 0.01 e(-)/s/pixel) environment. We describe results from the JWST Detector Characterization Project that is being performed in the LDTL. In this project, we are measuring first-order detector parameters, i.e. dark current, read noise, QE, intra-pixel sensitivity, linearity, as functions of temperature, well size, and operational mode.

Figer, Donald F.↗

NASA NTRS1992

Meiosis, egg activation, and nuclear envelope breakdown are differentially reliant on Ca2+, whereas germinal vesicle breakdown is Ca2+ independent in the mouse oocyte

During early development, intracellular Ca2+ mobilization is not only essential for fertilization, but has also been implicated during other meiotic and mitotic events, such as germinal vesicle breakdown (GVBD) and nuclear envelope breakdown (NEBD). In this study, the roles of intracellular and extracellular Ca2+ were examined during meiotic maturation and reinitiation at parthenogenetic activation and during first mitosis in a single species using the same methodologies. Cumulus-free metaphase II mouse oocytes immediately resumed anaphase upon the induction of a large, transient Ca2+ elevation. This resumption of meiosis and associated events, such as cortical granule discharge, were not sensitive to extracellular Ca2+ removal, but were blocked by intracellular Ca2+ chelators. In contrast, meiosis I was dependent on external Ca2+; in its absence, the formation and function of the first meiotic spindle was delayed, the first polar body did not form and an interphase-like state was induced. GVBD was not dependent on external Ca2+ and showed no associated Ca2+ changes. NEBD at first mitosis in fertilized eggs, on the other hand, was frequently, but not always associated with a brief Ca2+ transient and was dependent on Ca2+ mobilization. We conclude that GVBD is Ca2+ independent, but that the dependence of NEBD on Ca2+ suggests regulation by more than one pathway. As cells develop from Ca(2+)-independent germinal vesicle oocytes to internal Ca(2+)-dependent pronuclear eggs, internal Ca2+ pools increase by approximately fourfold.

Non-NASA Center↗

NASA NTRS2005

Development of a gravity-independent wastewater bioprocessor for advanced life support in space

Operation of aerobic biological reactors in space is controlled by a number of challenging constraints, mainly stemming from mass transfer limitations and phase separation. Immobilized-cell packed-bed bioreactors, specially designed to function in the absence of gravity, offer a viable solution for the treatment of gray water generated in space stations and spacecrafts. A novel gravity-independent wastewater biological processor, capable of carbon oxidation and nitrification of high-strength aqueous waste streams, is presented. The system, consisting of a fully saturated pressurized packed bed and a membrane oxygenation module attached to an external recirculation loop, operated continuously for over one year. The system attained high carbon oxidation efficiencies often exceeding 90% and ammonia oxidation reaching approximately 60%. The oxygen supply module relies on hydrophobic, nonporous, oxygen selective membranes, in a shell and tube configuration, for transferring oxygen to the packed bed, while keeping the gaseous and liquid phases separated. This reactor configuration and operating mode render the system gravity-independent and suitable for space applications.

NASA Discipline Life Support Systems↗

NASA NTRS2006

Process Demonstration For Lunar In Situ Resource Utilization-Molten Oxide Electrolysis (MSFC Independent Research and Development Project No. 5-81)

The purpose of this Focus Area Independent Research and Development project was to conduct, at Marshall Space Flight Center, an experimental demonstration of the processing of simulated lunar resources by the molten oxide electrolysis process to produce oxygen and metal. In essence, the vision was to develop two key technologies, the first to produce materials (oxygen, metals, and silicon) from lunar resources and the second to produce energy by photocell production on the Moon using these materials. Together, these two technologies have the potential to greatly reduce the costs and risks of NASA s human exploration program. Further, it is believed that these technologies are the key first step toward harvesting abundant materials and energy independent of Earth s resources.

Curreri, P. A.↗