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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 181 records · Page 10
All sourcesNASA NTRSDOE OSTI
NASA NTRS1995

Human osteoblast-like cells respond to mechanical strain with increased bone matrix protein production independent of hormonal regulation

Exposure of osteosarcoma cell lines to chronic intermittent strain increases the activity of mechano-sensitive cation (SA-cat) channels. The impact of mechano-transduction on osteoblast function has not been well studied. We analyzed the expression and production of bone matrix proteins in human osteoblast-like osteosarcoma cells, OHS-4, in response to chronic intermittent mechanical strain. The OHS-4 cells exhibit type I collagen production, 1,25-Dihydroxyvitamin D-inducible osteocalcin, and mineralization of the extracellular matrix. The matrix protein message level was determined from total RNA isolated from cells exposed to 1-4 days of chronic intermittent strain. Northern analysis for type I collagen indicated that strain increased collagen message after 48 h. Immunofluorescent labeling of type I collagen demonstrated that secretion was also enhanced with mechanical strain. Osteopontin message levels were increased several-fold by the application of mechanical load in the absence of vitamin D, and the two stimuli together produced an additive effect. Osteocalcin secretion was also increased with cyclic strain. Osteocalcin levels were not detectable in vitamin D-untreated control cells. However, after 4 days of induced load, significant levels of osteocalcin were observed in the medium. With vitamin D present, osteocalcin levels were 4 times higher in the medium of strained cells compared to nonstrained controls. We conclude that mechanical strain of osteoblast-like cells is sufficient to increase the transcription and secretion of matrix proteins via mechano-transduction without hormonal induction.

NASA Discipline Number 40-40↗
NASA NTRS2005

Artificial Gravity Research Project

Protecting the health, safety, and performance of exploration-class mission crews against the physiological deconditioning resulting from long-term weightlessness during transit and long-term hypogravity during surface operations will require effective, multi-system countermeasures. Artificial gravity (AG), which would replace terrestrial gravity with inertial forces generated by rotating the transit vehicle or by a human centrifuge device within the transit vehicle or surface habitat, has long been considered a potential solution. However, despite its attractiveness as an efficient, multi-system countermeasure and its potential for improving the environment and simplifying operational activities (e.g., WCS, galley, etc.), much still needs to be learned regarding the human response to rotating environments before AG can be successfully implemented. This paper will describe our approach for developing and implementing a rigorous AG Research Project to address the key biomedical research questions that must be answered before developing effective AG countermeasure implementation strategies for exploration-class missions. The AG Research Project will be performed at JSC, ARC, extramural academic and government research venues, and international partner facilities maintained by DLR and IMBP. The Project includes three major ground-based human research subprojects that will lead to flight testing of intermittent short-radius AG in ISS crewmembers after 201 0, continuous long-radius AG in CEV crews transiting to and from the Moon, and intermittent short-radius AG plus exercise in lunar habitats. These human ground-based subprojects include: 1) a directed, managed international short-radius project to investigate the multi-system effectiveness of intermittent AG in human subjects deconditioned by bed rest, 2) a directed, managed long-radius project to investigate the capacity of humans to live and work for extended periods in rotating environments, and 3) a focused, investigator-initiated project to investigate system-specific adaptation to and from rotating environments. The AG Research Project also includes two major animal research subprojects: 1) a directed, managed ground-based subproject using rodents and, possibly, sub-human primates, to address mechanistic issues that cannot be studied in humans, to rapidly develop higher sample numbers than can be achieved in the human subprojects, and to establish feasible parameter operating bands to reduce the breadth of the human subprojects, and 2) a flight subproject using rodents to estimate the physiological effects of long term exposure to hypogravity and to investigate the effects of contamination by terrestrial gravity in estimating AG effectiveness. The animal flight subproject would be performed aboard ISS using the CAM module in approximately the 2008-201 1 timeframe. The paper will first present an overview of the key biomedical research questions to be answered. It will then describe the overall approaches to be utilized in developing and implementing the AG Research Project, including definition of the intended scientific research, management and development approaches, identification of roles and responsibilities, risk management, and definition of project deliverables. The primary focus of the paper will be on the first of the three ground-based human research subprojects, since it is the only one currently in development and is scheduled to start active subject investigations in April of 2005.

Kamman, Michelle R.↗
NASA NTRS2008

Analytical Model of the Nonlinear Dynamics of Cantilever Tip-Sample Surface Interactions for Various Acoustic-Atomic Force Microscopies

A comprehensive analytical model of the interaction of the cantilever tip of the atomic force microscope (AFM) with the sample surface is developed that accounts for the nonlinearity of the tip-surface interaction force. The interaction is modeled as a nonlinear spring coupled at opposite ends to linear springs representing cantilever and sample surface oscillators. The model leads to a pair of coupled nonlinear differential equations that are solved analytically using a standard iteration procedure. Solutions are obtained for the phase and amplitude signals generated by various acoustic-atomic force microscope (A-AFM) techniques including force modulation microscopy, atomic force acoustic microscopy, ultrasonic force microscopy, heterodyne force microscopy, resonant difference-frequency atomic force ultrasonic microscopy (RDF-AFUM), and the commonly used intermittent contact mode (TappingMode) generally available on AFMs. The solutions are used to obtain a quantitative measure of image contrast resulting from variations in the Young modulus of the sample for the amplitude and phase images generated by the A-AFM techniques. Application of the model to RDF-AFUM and intermittent soft contact phase images of LaRC-cp2 polyimide polymer is discussed. The model predicts variations in the Young modulus of the material of 24 percent from the RDF-AFUM image and 18 percent from the intermittent soft contact image. Both predictions are in good agreement with the literature value of 21 percent obtained from independent, macroscopic measurements of sheet polymer material.

Cantrell, John H., Jr.↗
NASA NTRS2000

A Primary Care Approach to the Diagnosis and Management of Peripheral Arterial Disease

The objectives of this work are: (1) Be able to recognize characteristic symptoms of intermittent claudication (2) Diagnose PAD on the basis of history, physical exam, and simple limb blood pressure measurements (3) Recognize the significance of peripheral artery disease as a marker for coronary or cerebrovascular atherosclerosis (4) Provide appropriate medical management of atherosclerosis risk factors-- including use of antiplatelet therapy to reduce risk of myocardial infarction, stroke and death (5) Manage symptoms of intermittent claudication with program of smoking cessation, exercise, and medication The diagnosis of intermittent claudication secondary to peripheral artery disease (PAD) can often be made on the basis of history and physical examination. Additional evaluation of PAD is multi-modal and the techniques used will vary depending on the nature and severity of the patient's presenting problem. Most patients can be appropriately managed without referral for specialized diagnostic services or interventions.

Dawson, David L.↗
NASA NTRS2020

Exploring Spatiotemporal Relations Between Soil Moisture, Precipitation, and Streamflow for a Large Set of Watersheds Using Google Earth Engine

An understanding of streamflow variability and its response to changes in climate conditions is essential for water resource planning and management practices that will help to mitigate the impacts of extreme events such as floods and droughts on agriculture and other human activities. This study investigated the relationship between precipitation, soil moisture, and streamflow over a wide range of watersheds across the United States using Google Earth Engine (GEE). The correlation analyses disclosed a strong association between precipitation, soil moisture, and streamflow, however, soil moisture was found to have a higher correlation with the streamflow relative to precipitation. Results indicated different strength of the association depends on the watershed classes and lag times assessments. The perennial watersheds showed higher coherence compared to intermittent watersheds. Previous month precipitation and soil moisture have a stronger influence on the current month streamflow, particularly in the snow-dominated watersheds. Monthly streamflow forecasting models were developed using an autoregressive integrated moving average (ARIMA) and support vector machine (SVM). The results showed that the SVM model generally performed better than the ARIMA model. Overall streamflow forecasting model performance varied considerably among watershed classes, and perennial watersheds tend to exhibit better predictably compared to intermittent watersheds due to lower streamflow variability. The SVM models with precipitation and streamflow inputs performed better than those with streamflow input only. Results indicated that the inclusion of antecedent root-zone soil moisture improved the streamflow forecasting in most of the watersheds, and the largest improvements occurred in the intermittent watersheds. In conclusion, this work demonstrated that knowing the relationship between precipitation, soil moisture, and streamflow in different watershed classes will enhance the understanding of the hydrologic process and can be effectively utilized in improving streamflow forecasting for better satellite-based water resource management strategies.

Nazmus Sazib↗
NASA NTRS2018

High Resolution Computed Tomography Inspection of Components Uncovers Root Causes of Vexing Failure Mysteries

During testing of actuators for fight programs, failures have occurred that required closure with an understanding of the root cause of the failure. For some InSight project actuators, intermittent changes of the winding resistance of the motors during temperature changes was extremely baffling. It was critical to determine the cause of the intermittent characteristic because the actuators were stock from a previous program and the company that provided the motors was no longer in business. Using an X-Ray Computed-Tomography (CT) method, the exact source of the intermittent failure was determined and completely understood – at dimensions of less than 20 microns. In another case, after the completion of an actuator’s life-test-to-failure, inspection was required to determine the source of the failure. The size of the actuator (10 mm diameter) required destructive means to get to the interior of the actuator for inspection, risking the loss of the source of the failure. Using CT imaging, the exact source of the failure was determined.

Johnson, Michael R.↗
NASA NTRS1971

Stimulation of cardiovascular adaptability during prolonged space exposure

The deconditioning effects of weightlessness on the cardiovascular system of astronauts are discussed. It is believed that man cannot tolerate indefinite exposure to weightlessness without considerable circulatory deterioration. Analyses of data collected from space flights to date substantiate these beliefs, and confirm the fact that some form of compensation must be provided to keep the cardiovascular system of space travelers properly conditioned. Sequential pulsatile devices were investigated to produce periodic hydrostatic pressure gradients in the venous system of eight subhuman primates. Intermittent venous pooling of blood in the extremities triggers and stimulates the vascular reflex mechanisms of the cardiovascular system that may have significant benefits in maintaining the circulatory system in proper tone under weightless conditions. Electrocardiograms, blood pressure measurements, cardiac output and stroke volume determinations were used to evaluate the efficiency of the described technique. Results were amazingly consistent to indicate an efficient system for intermittently exercising the heart within safe and medically acceptable limits.

Gorman, H. A.↗
NASA NTRS1966

A computer simulation experiment of supervisory control of remote manipulation

A computer simulation of a remote manipulation task and a rate-controlled manipulator is described. Some low-level automatic decision making ability which could be used at the operator's discretion to augment his direct continuous control was built into the manipulator. Experiments were made on the effect of transmission delay, dynamic lag, and intermittent vision on human manipulative ability. Delay does not make remote manipulation impossible. Intermittent visual feedback, and the absence of rate information in the display presented to the operator do not seem to impair the operator's performance. A small-capacity visual feedback channel may be sufficient for remote manipulation tasks, or one channel might be time-shared between several operators. In other experiments the operator called in sequence various on-site automatic control programs of the machine, and thereby acted as a supervisor. The supervisory mode of operation has some advantages when the task to be performed is difficult for a human controlling directly.

Mccandlish, S. G.↗
NASA NTRS1971

Optimal flash rate and duty cycle for flashing visual indicators.

This experiment examined the ability of observers to determine, as quickly as possible, whether a visual indicator was steadily on or flashing. Six flash rates (periods) were combined factorially with three duty cycles (on-off ratios) to define 18 ?types' of intermittent signals. Experimental sessions were divided into six runs of 100 trials, each run utilizing one of the six flash rates. On any given trial in a run, the probability of a steady signal occurring was 0.5 and the probability of a flashing signal occurring was 0.5. A different duty cycle was employed daily for each experimental session. In all, 400 trials were devoted to each of the flash rates at each duty cycle. Accuracy and latency of response were the dependent variables of interest. The results show that the observers view the light for an interval of time appropriate to the expected flash rate and duty cycle; whether they judge the light to be steady or intermittent depends upon whether the light is extinguished during the predetermined waiting period. Adoption of this temporal criterion delays responding in comparison to those tasks involving responses to light onset. The decision or response criteria held by the observers are also sensitive to the parameters of the flashing light: observers become increasingly willing to call a flashing light ?steady' as flash duration increases.

Markowitz, J.↗
NASA NTRS1974

Turbulence measurements in an equilibrium hypersonic boundary layer

New quantitative turbulence measurements were obtained in a constant pressure, nonadiabatic hypersonic boundary layer, including the first higher moment and probability density measurements of mass-flow and total temperature fluctuations in hypersonic flow. The mass-flow and total temperature fluctuations show that the hypersonic data do not follow the trends set by lower Mach number adiabatic results. Measured intermittency distributions indicate substantial intermittency in the viscous sublayer and in the outer flow; significant differences between the present data and incompressible results are apparent. The higher moment and probability density data show that the character of the mass-flow and total temperature fluctuation modes are significantly different across the entire boundary layer. These differences together with turbulence scale and lifetime data obtained from autocorrelation and space-time correlation measurements are also discussed.-

Owen, F. K.↗
NASA NTRS1975

Fiber reinforced solids possessing great fracture toughness: The role of interfacial strength

The results of angle-ply investigations for strength and toughness of brittle fiber/brittle filament composites are presented. General results are discussed for both unidirectional and angle-ply intermittently bonded boron/epoxy composites as affected by soaking and freezing water environments. A description of and the operating instructions are included for the modified 230 mm (9 inch) wide intermittent coating tape making apparatus.

Atkins, A. G.↗
NASA NTRS1975

Aerothermal performance and structural integrity of a Rene 41 thermal protection system at Mach 6.6

A flightweight panel based on a metallic thermal-protection-system concept for hypersonic and reentry vehicles was subjected repeatedly to thermal cycling by quartz-lamp radiant heating using a thermal history representative of a reentry heat pulse and to aerodynamic heating at heating rates required to sustain a surface temperature of 1089 K (1960 R). The panel consisted of a corrugated heat shield and support members of 0.05-cm (0.02-in.) thick Rene 41 of riveted construction and 5.08-cm (2-in.) thick silica fibrous insulation packages covered by Rene 41 foil and inconel screening. All tests were conducted in the Langley 8-foot high-temperature structures tunnel with the heat shield corrugations alined in the stream direction. The panel sustained 5.33 hr of intermittent radiant heating and 6.5 min of intermittent aerodynamic heating of up to 1-min duration for differential pressures up to 6.2 kPa (0.9 psi) with no apparent degradation of thermal or structural integrity, as indicated by temperature distributions and results from load deflection tests and vibration surveys of natural frequencies.

Deveikis, W. D.↗
NASA NTRS1976

Macroscopic study of time unsteady noise of an aircraft engine during static tests

Static tests of aircraft engines can exhibit greater than 10 db random unsteadiness of tone noise levels because flow disturbances that prevail near test site facilities are ingested. Presumably such changes are related to installation and test site features. Some properties of unsteady noise observed during tests of a Lycoming YF-102 turbofan engine are presented. Time and spatial variations in tone noise obtained from closely spaced far field and inlet duct microphones are displayed. Long to extremely short intermittent tone bursts are observed. Unsteadiness of the tone, its harmonics, and the broadband noise show little similarity. In the far field, identity of tone bursts is retained over a directivity angle of less than 10 deg. In the inlet duct, tone bursts appear to propagate axially but exhibit little circumferential similarity. They show only slight relationship to tone bursts observed in the far field. The results imply an intermittent generation of random mixtures of propagating duct modes.

Clark, B. J.↗
NASA NTRS1976

Electrically rechargeable REDOX flow cell

A bulk energy storage system is designed with an electrically rechargeable reduction-oxidation (REDOX) cell divided into two compartments by a membrane, each compartment containing an electrode. An anode fluid is directed through the first compartment at the same time that a cathode fluid is directed through the second compartment. Means are provided for circulating the anode and cathode fluids, and the electrodes are connected to an intermittent or non-continuous electrical source, which when operating, supplies current to a load as well as to the cell to recharge it. Ancillary circuitry is provided for disconnecting the intermittent source from the cell at prescribed times and for circulating the anode and cathode fluids according to desired parameters and conditions.

Thaller, L. H.↗
NASA NTRS1976

Measurements in the mixing region of a turbulent jet in a coflowing airstream

The mixing region of a turbulent jet is an important example of an intermittent turbulent shear flow. There are a great deal of interest in this region because of interest in jet noise and STOL aircraft which use upper surface blowing or externally blown flap configurations to increase lift. A detailed study of the one point statistical properties of a smoke laden jet was made using a combination of a laser velocimeter and a light scattering system. The jet, with a 14 to 1 contraction, was placed inside a wind tunnel where the ratio of the jet exit velocity to free stream was 5.1 to 1. All measurements are made for a jet Reynolds number of 22,600. Among the quantities measured are mean axial and radial velocities, axial and radial intensities, power spectra, mean smoke concentration, concentration intensities, concentration spectra, intermittencies and velocity-concentration correlations. The results are compared with hot-wire data where available.

Morton, J. B.↗
NASA NTRS1977

An experimental investigation of a three-dimensional wall jet

An experimental investigation of the effects of a curved and flat wall surface on the flow development of an axisymmetric jet exhausting into a moving airstream has been made. Of primary concern was the comparison of the one-point statistical properties of the unconfined jet to the quantities measured in the flows over a flat plate and a curved wall surface. Quantities measured in this investigation included mean velocities in all three directions, turbulent intensities, autocorrelations, power spectral densities, and intermittencies. The investigation was confined to the near field of the turbulent jet. The curved wall (flap) was found to have a very large effect on both the mean velocity and the turbulent velocity components of the flowfield. The potential core region of the jet was found to break up most rapidly for the flow over the flap. A laser-Doppler velocimeter, using a phase locked-loop processor, was used to make the desired velocity field measurements. To determine the intermittency profiles, a laser light scattering technique was employed.

Catalano, G. D.↗
NASA NTRS1976

Macroscopic study of time unsteady noise of an aircraft engine during static tests

Static tests of aircraft engines can exhibit greater than 10 dB random unsteadiness of tone noise levels because flow disturbances that prevail near test site facilities are ingested. Presumably such changes are related to installation and test site features. This paper presents some properties of unsteady noise observed at a NASA-Lewis facility during tests of a Lycoming YF-102 turbofan engine. Time and spatial variations in tone noise obtained from closely spaced far-field and inlet duct microphones are displayed. Long (0.5 sec) to extremely short (0.001 sec) intermittent tone bursts are observed. Unsteadiness of the tone, its harmonics, and the broadband noise show little similarity. In the far-field, identity of tone bursts is retained over a directivity angle of less than 10 deg. In the inlet duct, tone bursts appear to propagate axially but exhibit little circumferential similarity. They show only slight relationship to tone bursts observed in the far field. The results imply an intermittent generation of random mixtures of propagating duct modes.

Clark, B. J.↗
NASA NTRS1978

Experimental analysis and computation of the onset and development of the boundary layer transition

The transition of an incompressible boundary layer, with zero pressure gradient and low free-stream turbulence is studied. Mean velocity, turbulence and Reynolds shear stress profiles are presented. The development of the Tollmien-Schlichting waves is clearly shown until the turbulent spots appear. The intermittency phenomenon is studied by conditional sampling of the hotwire signal. The comparison with calculation results obtained by resolution of a set of transport equations shows a good agreement for the mean characteristics of the flow; discrepancies observed for the turbulent quantities evolution are due to the intermittency phenomenon.

Arnal, D.↗