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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 181 records · Page 10
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

S&TR Jan-Feb 2024 (Wind Tunnel - EMIT Issue)

At Lawrence Livermore National Laboratory, we focus on science and technology research to ensure our nation’s security. We also apply that expertise to solve other important national problems in energy, bioscience, and the environment. Science & Technology Review is published eight times a year to communicate, to a broad audience, the Laboratory’s scientific and technological accomplishments in fulfilling its primary missions. The publication’s goal is to help readers understand these accomplishments and appreciate their value to the individual citizen, the nation, and the world.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2025

Structural Insights into the Dynamics of Water in SOD1 Catalysis and Drug Interactions

Superoxide dismutase 1 (SOD1) is a crucial enzyme that protects cells from oxidative damage by converting superoxide radicals into H 2 O 2 and O 2 . This detoxification process, essential for cellular homeostasis, relies on a precisely orchestrated catalytic mechanism involving the copper cation, while the zinc cation contributes to the structural integrity of the enzyme. This study presents the 2.3 Å crystal structure of human SOD1 (PDB ID: 9IYK), revealing an assembly of six homodimers and twelve distinct active sites. The water molecules form a complex hydrogen-bonding network that drives proton transfer and sustains active site dynamics. Our structure also uncovers subtle conformational changes that highlight the intrinsic flexibility of SOD1, which is essential for its function. Additionally, we observe how these dynamic structural features may be linked to pathological mutations associated with amyotrophic lateral sclerosis (ALS). By advancing our understanding of hSOD1’s mechanistic intricacies and the influence of water coordination, this study offers valuable insights for developing therapeutic strategies targeting ALS. Our structure’s unique conformations and active site interactions illuminate new facets of hSOD1 function, underscoring the critical role of structural dynamics in enzyme catalysis. Moreover, we conducted a molecular docking analysis using SOD1 for potential radical scavengers and Abelson non-receptor tyrosine kinase (c-Abl, Abl1) inhibitors targeting misfolded SOD1 aggregation along with oxidative stress and apoptosis, respectively. The results showed that CHEMBL1075867, a free radical scavenger derivative, showed the most promising docking results and interactions at the binding site of hSOD1, highlighting its promising role for further studies against SOD1-mediated ALS.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2006

High Power Laser Diode Array Qualification and Guidelines for Space Flight Environments

High-power laser diode arrays (LDAs) are used for a variety of space-based remote sensor laser programs as an energy source for diode-pumped solid-state lasers. LDAs have been flown on NASA missions including MOLA, GLAS and MLA and have continued to be viewed as an important part of the laser-based instrument component suite. There are currently no military or NASA-grade, -specified, or - qualified LDAs available for "off-the-shelf" use by NASA programs. There has also been no prior attempt to define a standard screening and qualification test flow for LDAs for space applications. Initial reliability studies have also produced good results from an optical performance and stability standpoint. Usage experience has shown, howeve that the current designs being offered may be susceptible to catastrophic failures due to their physical construction (packaging) combined with the electro-optical operational modes and the environmental factors of space application. design combined with operational mode was at the root of the failures which have greatly reduced the functionality of the GLAS instrument. The continued need for LDAs for laser-based science instruments and past catastrophic failures of this part type demand examination of LDAs in a manner which enables NASA to select, buy, validate and apply them in a manner which poses as little risk to the success of the mission as possible.

Ott, Melanie N.↗
NASA NTRS1998

A Combined Laser-Communication and Imager for Microspacecraft (ACLAIM)

ACLAIM is a multi-function instrument consisting of a laser communication terminal and an imaging camera that share a common telescope. A single APS- (Active Pixel Sensor) based focal-plane-array is used to perform both the acquisition and tracking (for laser communication) and science imaging functions.

Laser Communication Optical Communication Science ↗
NASA NTRS2011

Apollo Lunar Sample Photographs: Digitizing the Moon Rock Collection

The Acquisition and Curation Office at JSC has undertaken a 4-year data restoration project effort for the lunar science community funded by the LASER program (Lunar Advanced Science and Exploration Research) to digitize photographs of the Apollo lunar rock samples and create high resolution digital images. These sample photographs are not easily accessible outside of JSC, and currently exist only on degradable film in the Curation Data Storage Facility

Lofgren, Gary E.↗
NASA NTRS1999

Atmospheric Science Measurements by the EOS Geoscience Laser Altimeter System

Scheduled for Launch in July 2001, the Geoscience Laser Altimeter System (GLAS) is to be the first satellite instrument to provide full global lidar profiling of clouds and aerosol in the earth's atmosphere. GLAS is an EOS program instrument that is on its own satellite, now called the Ice, Cloud and land Elevation Satellite. The instrument is both a surface laser ranging system and an atmospheric profiling lidar. A most important surface measurement for the instrument is to study the change in the mass balance of the polar ice sheets by measuring the change in regional altitudes to an accuracy of 1.5 cm per year. The strategy to combine the surface measurement with a Cloud and aerosol lidar profiling mission is based on the compatibility of the altimetry instrument requirements with those for the required lidar measurements. The primary atmospheric science goal of the GLAS cloud and aerosol measurement is to determine the radiative forcing and vertically resolved atmospheric heating rate due to cloud and aerosol by directly observing the vertical structure and magnitude of cloud and aerosol parameters that are important for the radiative balance of the earth-atmosphere system, but which are ambiguous or impossible to obtain from existing or planned passive remote sensors. A further goal is to directly measure the height of atmospheric transition layers (inversions) which are important for dynamics and mixing, the planetary boundary layer and lifting condensation level.

Spinhirne, James↗
NASA NTRS1979

Lunar laser ranging data deposited in the National Space Science Data Center normal points, filtered observations, and unfiltered photon detections

The lunar laser ranging project at McDonald Observatory provides the unique opportunity to acquire successfully precise range data for the earth-moon system. From the experiment's inception, the obligation was recognized to make these data available to the general scientific community in a reasonably useable form and in a realistic time frame. The documentation to be used in conjunction with the 1979 April deposit into the National Space Science Data Center which contains normal points, filtered observations and unfiltered photon stops for the months July through December, 1978 are reported.

Shelus, P. J.↗