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NASA NTRS2002

Computational Model of the Modulation of Gene Expression Following DNA Damage

High linear energy transfer (LET) radiation, such as heavy ions or neutrons, has an increased biological effectiveness compared to X rays for gene mutation, genomic instability, and carcinogenesis. In the traditional paradigm, mutations or chromosomal aberrations are causative of late effects. However, in recent years experimental evidence has demonstrated the important role of the description of the modification of gene expression by radiation in understanding the mechanisms of radiation action. In this report, approaches are discussed to the mathematical description of mRNA and protein expression kinetics following DNA damage. Several hypotheses for models of radiation modulation of protein expression are discussed including possible non-linear processes that evolve from the linear dose responses that follow the initial DNA damage produced by radiation.

NASA Center JSC↗

DOE OSTI2024

Bidentate Lewis Base Ligand-Mediated Surface Stabilization and Modulation of the Electronic Structure of CsPbBr 3 Perovskite Nanocrystals

The desorption of conventional ligands from the surface of halide perovskite nanocrystals (NCs) often causes their structural instability and the deterioration of the optoelectronic properties. To address this challenge, we present an approach of using a bidentate Lewis base ligand, namely, 1,4-bis(diphenylphosphino)butane (DBPP), for the synthesis of CsPbBr 3 NCs. The phosphine group of DBPP has a strong interaction with PbBr 2 precursor, forming a highly crystalline intermediate complex during the reaction. In the presence of oleic acid, the uncoordinated phosphine group of DBPP is converted into the phosphonium cation, which strongly binds with the surface bromide of the formed CsPbBr 3 NCs through hydrogen bonding. Density functional theory calculations suggest that DBPP can strongly bind to the undercoordinated lead and surface bromide ions of CsPbBr 3 NCs through its unprotonated and protonated phosphine groups, respectively. The robust binding of DBPP with the surface of perovskite NCs helps to preserve their structural integrity under various environmental stresses. Moreover, the electron density and energy levels are regulated in DBPP-capped CsPbBr 3 NCs via the efficient transfer of electrons from the ligands to the NCs, resulting in their improved photocatalytic CO 2 reduction performance. Furthermore, our study highlights the potential of using bidentate ligands to stabilize the surface of perovskite NCs and modulate their optical and electronic properties.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

NASA NTRS1985

Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Test act system validation

The primary objective of the Test Active Control Technology (ACT) System laboratory tests was to verify and validate the system concept, hardware, and software. The initial lab tests were open loop hardware tests of the Test ACT System as designed and built. During the course of the testing, minor problems were uncovered and corrected. Major software tests were run. The initial software testing was also open loop. These tests examined pitch control laws, wing load alleviation, signal selection/fault detection (SSFD), and output management. The Test ACT System was modified to interface with the direct drive valve (DDV) modules. The initial testing identified problem areas with DDV nonlinearities, valve friction induced limit cycling, DDV control loop instability, and channel command mismatch. The other DDV issue investigated was the ability to detect and isolate failures. Some simple schemes for failure detection were tested but were not completely satisfactory. The Test ACT System architecture continues to appear promising for ACT/FBW applications in systems that must be immune to worst case generic digital faults, and be able to tolerate two sequential nongeneric faults with no reduction in performance. The challenge in such an implementation would be to keep the analog element sufficiently simple to achieve the necessary reliability.

Source record↗

DOE OSTI2025

Relative Contributions of Surface Parcel and Atmospheric Environment to Convective Potential during Interstorm Periods

Convective instability is affected by both surface heat fluxes into near-surface air parcels and the atmospheric profile encountered as these air parcels are lifted aloft. In this study, we investigate the evolution of buoyancy experienced by surface-based parcels, taking interstorm soil moisture drydowns as fundamental time periods. We use profile observations of atmospheric temperature and humidity from ground-based passive remote sensing and in situ observations available at the U.S. Department of Energy Atmospheric Radiation Measurement Southern Great Plains site in Oklahoma, United States, and examine drydown events during the warm seasons from 2017 to 2022. Results reveal new insights on the emergence and growth of convective available potential energy (CAPE) during drydowns. We observe that the peak convective potential appears in the afternoon and grows in the midtroposphere (68% of 66 drydown events), with the largest CAPE values toward the end of the drydown event. We also find that the near-surface parcel contributes more to the evolution of CAPE than the atmospheric environment (86% of drydown events). These findings highlight the importance of surface heat fluxes and moisture availability from surface-based parcels in modulating the evolution of atmospheric conditions favorable for convection, underscoring the interplay between surface processes and atmospheric dynamics in driving convective instability.

Atmosphere-land interaction↗

DOE OSTI2025

Convective shells in the interior of Cepheid variable stars: Overshooting models based on hydrodynamic simulations

Context. Because Cepheid variable stars have long been used as a cosmic benchmark for scaling distances in our Galaxy and beyond, the accuracy of stellar evolution models for Cepheids have wide-reaching effects. However, our understanding of the dynamics in the interiors of these physically complex stars is limited. Aims. Our goal is to provide a detailed multi-dimensional picture of hydrodynamic convection and convective boundary mixing in the interior of Cepheids. Methods. Using the Modules for Experiments in Stellar Astrophysics (MESA), we studied the structure of intermediate-mass stars that cross the instability strip. Then, we performed two-dimensional hydrodynamic simulations of six stars with the fully compressible Multidimensional Stellar Implicit Code (MUSIC). Our simulations did not model the radial pulsations but focused on the interior structure of this family of stars. We developed and applied a new statistical analysis to examine convection and convective boundary mixing in the interior of these stellar simulations. Results. Based on a grid of MESA models, we demonstrated that a common structure for intermediate mass Cepheids includes an interior convective shell as well as a thin outer convective envelope. Using the extreme value theory approach to analyze our MUSIC simulation data, we found that overshooting above the convective shell fills the space between these convectively unstable layers. We developed a new statistical analysis that provides a clearer picture of how overshooting fills this layer; it also allowed us to formulate a detailed comparison between overshooting above and below the convective shell. Our analysis effectively decomposes the overshooting layer into two layers: a weak overshooting layer and a strong overshooting layer. Statistically, this is accomplished by decomposing the strongly non-Gaussian probability density function into a mixture of gamma distributions. Using our mixture model, we showed that the ratio of overshooting lengths above and below the convective shell depends directly on the radial extent of the convective shell as well as its depth in the star. We proposed a new form for the diffusion coefficient that addresses the need for overlapping overshooting layers between convective shells. We introduced the idea of a “super-mixing layer” where overshooting from both the convective shell and the convective envelope results in efficient mixing and could be viewed as merging the two adjacent convective zones.

79 ASTRONOMY AND ASTROPHYSICS↗

NASA NTRS1988

Nature and the nonlinear evolution of electrostatic waves associated with the AMPTE solar wind releases

The nonlinear evolution of the electrostatic waves observed during the AMPTE (Active Magnetosphere Particle Tracer Explorers) solar wind releases is investigated. Previous linear studies indicate two distinct sets of instabilities may be responsible for the generation. One set consists of ion-acoustic type instabilities which are insensitive to the presence of a background magnetic field, while the other group corresponds to the modified two stream instabilities and requires the solar wind flow to be across the ambient magnetic field. To establish which set of instabilities is more viable a detailed linear Vlasov theory has been conducted by numerically solving the full electromagnetic dispersion relation. In addition both the plasma wave as well as the magnetic field measurements by the IRM (Ion Release Module) spacecraft were used to correlate the frequency and the power of the observed waves with the magnitude and the direction of the solar wind magnetic field. The results of these analyses indicate that the ion-acoustic type instabilities have growth rates that are an order of magnitude or more larger than those of the modified two stream instabilities. Results show that both the solar wind protons and the released ions may be heated and accelerated in the directions oblique to the solar wind flow velocity.

Omidi, N.↗

NASA NTRS1973

Modulation of the Jovian decametric radio emission by IO

It is argued that the sweeping of trapped energetic MeV protons by Io can result in induced emissions. The instability is caused by the density gradient occurring at the edge of the cavity. It is shown that the azimuthal Larmor drift of the energetic protons which is transverse to both the local magnetic field and the density gradient can excite extraordinary waves with frequencies slightly above the local electron cyclotron frequency. It is found that the emission coefficient is proportional to the square root of (n sub p/n sub t), where n sub p and n sub t denote the density of the energetic protons and the density of the thermal electrons, respectively. The theory also predicts a lower frequency cutoff. This cutoff frequency depends upon the density of thermal electrons in the source region.

Wu, C. S.↗

NASA NTRS1978

Use of computers to exclude the influence of radiometer instability upon measurement results

A radiometer, practically insensitive to great fluctuations in the equipment amplification coefficient, was developed by dividing the useful signal by a reference signal and modulating the two signals at different frequencies. The signals are simultaneously separated by corresponding synchronous detectors and recorded over two channels. The operation is simplified by replacing the continuous signals by a sampling of discrete values, and using a digital computer. The four steps involved in the process are described and a block diagram is included. This technique not only directly connects the radiometer with the computer, but also records all data provided by the control and signal channels.

Domnin, S. L.↗

DOE OSTI2026

Early Unloading After ACL Rupture and Prior to Surgical Restabilization in Mice Slows Post-Traumatic Osteoarthritis Progression

Purpose: People who sustain joint injuries such as anterior cruciate ligament (ACL) rupture often go on to develop post-traumatic osteoarthritis (PTOA). ACL injuries are often treated with ACL reconstruction, but there is typically a gap of several weeks between injury and surgery. However, it is unclear how loading or unloading of the injured joint during the early postinjury period affects the progression of PTOA. The goal of this study was to determine how unloading between noninvasive ACL injury and surgical restabilization of the injured joint affects PTOA progression in mice. Findings: Mice were subjected to noninvasive ACL injury or no injury followed by 1 week of hindlimb unloading (HLU) or normal cage activity. After 1 week of HLU or cage activity, mice underwent restabilization surgery or no surgery. ACL injury resulted in considerable epiphyseal trabecular bone loss regardless of HLU or cage activity. HLU groups exhibited significantly reduced chondrophyte/osteophyte formation, OA scoring, and synovitis at day 42. Single-cell RNA sequencing revealed that 1 week of HLU resulted in more neutrophils and less monocytes-macrophages in the injured joint. Conclusions: This study establishes that 1 week of HLU after ACL injury effectively slowed PTOA progression, suggesting that the early inflammatory response and joint instability play a key role in PTOA initiation and progression, and neutrophils and monocytes-macrophages play roles in the modulation. However, subsequent joint restabilization surgery caused greater inflammatory protease activity in the joint and exacerbated the loss of epiphyseal trabecular bone but did not significantly diminish OA score or synovitis.

ACL injury↗

NASA NTRS1986

Unstable-magnetic-drift waves in a plasma with temperature anisotropy

It is pointed out that under certain conditions, such as a weak electron temperature anisotropy, the magnetic-drift wave instability can become rather important, and the growth rate can be greater than the ion gyrofrequency when the scale length of the density gradient is comparable to, or shorter than, the thermal ion gyroradius. The instability is attributed to wave-electron interactions, and the growth rate is far greater than the case investigated by Krall and Rosenbluth (1963) who attributed the instability to wave-ion interactions. The anticipated vanishing of the instability is observed as epsilon sub n/epsilon sub B approaches zero. The presently observed instability may be used to explain the low-frequency fluctuations evidenced by the Active Particle Tracer Explorer Ion Release Module magnetometer measurements, and may contribute to the acceleration of ions along the plasma cometary tail.

Wu, C. S.↗

NASA NTRS1989

Local generation of electrostatic bursts at Comet Giacobini-Zinner - Modulation by steepened magnetosonic waves

The ICE spacecraft observed in the vicinity of Comet Giacobini-Zinner electrostatic noise with burstlike features seemingly modulated by the relative orientation of the interplanetary magnetic field and the solar wind velocity. The adequacy of ion acousticlike instabilities stimulated by photoelectron or newborn ion beams to the interpretation of the electrostatic bursts is discussed. It is concluded that the mode fed by the photoelectrons exhibits characteristics compatible with the observations.

Brinca, Armando L.↗

NASA NTRS1975

Symbol synchronizer assembly instability study, part 2

Data processing to develop a third-order phase model and to translate all such processed data to the frequency realm for further analysis was described. The frequency study yields a long frequency modulation (FM) drift sinusoid (1600-sec period), an impressed secondary drift wave with a period of about 116 sec, and a set of even harmonics of twice the ramp period-the latter arising from, and used to modify, the phase detector model. The result is applied secondarily to estimate the strong-signal SSA phase detector response "out-of-lock." Finally, the main drift components are verified against all available data, and the result is used to estimate minimum lock conditions and the SSA drift effect under normal operating modes. The instability problem appears marginally resolvable if the acquisition technique is modified.

Bunce, R. C.↗

DOE OSTI2026

Toroidal phase of post-disruption runaway electron loss to wall in presence of applied 3-D fields in DIII-D

The toroidal distribution of runaway electrons (REs) striking the centre post in DIII-D post-disruption RE final loss events is simulated utilizing the MARS-F code combined with the REORBIT module, by tracing the guiding-centre drift orbits of test REs in the presence of external (applied) plus internal (intrinsic instability) 3-D fields. To better recover the experimental results, three different equilibria with different safety factor profiles are adopted. Dominant resistive magnetohydrodynamic instabilities are found to be m/n=2/1, 3/2 and 1/1 modes (where m and n are the poloidal and toroidal mode numbers). Externally applied n=1 resonant magnetic perturbations (RMPs), with both even and odd parity configuration, are considered in each equilibrium. Locking of MHD instability to the applied RMPs is simulated by minimizing the total perturbed magnetic energy in the plasma. Here, the simulated toroidal locations, where most REs strike in the presence of an edge m/n= 2/1 instability and the n=1 RMPs in even parity, are found to agree well with experiments. Modeling also captures the measured n = 2 RE loss pattern on the wall for experiments where an edge m/n=3/2 instability is dominant instead of the m/n=2/1 mode. The key overall findings include (a) the measured global RE toroidal impact pattern in experiments can be explained by a locked resistive kink instability, (b) the toroidal phase of the locked mode is well predicted by minimizing the total perturbed magnetic energy, and (c) this edge locked mode determines the toroidal phase of the peak RE wall impact.

Bai, Xue [University of California San Diego, La J↗

NASA NTRS1990

Flow and acoustic properties of low Reynolds number underexpanded supersonic jets

An experimental program to investigate the flow and acoustic properties of model underexpanded supersonic jets was conducted. In particular, the role played by large-scale organized fluctuations in the flow evolution and acoustic production processes was examined in detail. The experimental conditions were chosen as low-Reynolds-number (Re = 8000) Mach 1.4 and 2.1 underexpanded jets exhausting from convergent nozzles. A consequence of performing the experiments at low Reynolds number is that the broadband shock-associated noise is suppressed. The focus of the present study is on the generation of noise by large-scale instabilities in the presence of strong shock cell structures. It is demonstrated that the production of screech is related to the modulation and decay of large-scale turbulence structures.

Hu, Tieh-Feng↗

NASA NTRS1994

Velocity-modulation atomization of liquid jets

A novel atomizer based on high-amplitude velocity atomization has been developed. Presently, the most common methods of atomization can use only the Rayleigh instability of a liquid cylinder and the Kelvin-Helmholtz instability of a liquid sheet. Our atomizer is capable of atomizing liquid jets by the excitation and destabilization of many other higher-order modes of surface deformation. The potential benefits of this sprayer are more uniform fuel air mixtures, faster fuel-air mixing, extended flow ranges for commercial nozzles, and the reduction of nozzle plugging by producing small drops from large nozzles.

Dressler, John L.↗

DOE OSTI2026

Atomic structure and formation mechanism of a newly discovered charge density wave in the m = 2 monophosphate tungsten bronze

The m = 2 member of the monophosphate tungsten bronze family had been thought to be the only one without an electronic instability at low temperature. In this paper, we report the discovery of a charge density wave phase in this compound, with a transition temperature of 290 K and an incommensurate modulation vector q = 0.245b* + ξc*, which reaches a lock-in with a commensurate vector at 130 K. The presence of this new phase is confirmed by diffraction and resistivity measurements. Pre-transitional dynamics are investigated using diffuse and inelastic X-ray scattering, revealing a clear Kohn anomaly. We analyze both structural and electronic contributions to the phase transition, providing a comprehensive picture of the mechanism driving this newly identified instability.

Minelli, Arianna [ORNL] (ORCID:0000000283103712)↗

NASA NTRS1990

Test results of a diffraction grating beam combiner

A laser diode beam combiner employing diffraction gratings has been fabricated and tested. The Grating Laser Beam Combiner (GLBC) uses two holographic diffraction gratings to incoherently combine the first order diffraction components of four 35 mW AlGaAs lasers. The grating rhomb design minimizes the transmitter sensitivity to the inherent frequency instability of laser diodes. The overall throughput of the combiner is 74 percent. Each laser was temperature controlled to 0.1 C and modulated with 110 Mbps QPPM data. Two lasers under modulation were coaligned to within 76 microrad with a combined average power of 45 mW.

Rall, Jonathan A.↗

NASA NTRS2016

Expanding the Natural Laminar Flow Boundary for Supersonic Transports

A computational design and analysis methodology is being developed to design a vehicle that can support significant regions of natural laminar flow (NLF) at supersonic flight conditions. The methodology is built in the CDISC design module to be used in this paper with the flow solvers Cart3D and USM3D, and the transition prediction modules BLSTA3D and LASTRAC. The NLF design technique prescribes a target pressure distribution for an existing geometry based on relationships between modal instability wave growth and pressure gradients. The modal instability wave growths (both on- and off-axes crossflow and Tollmien-Schlichting) are balanced to produce a pressure distribution that will have a theoretical maximum NLF region for a given streamwise wing station. An example application is presented showing the methodology on a generic supersonic transport wingbody configuration. The configuration has been successfully redesigned to support significant regions of NLF (approximately 40% of the wing upper surface by surface area). Computational analysis predicts NLF with transition Reynolds numbers (ReT) as high as 36 million with 72 degrees of leading-edge sweep (ΛLE), significantly expanding the current boundary of ReT - ΛLE combinations for NLF. This NLF geometry provides a total drag savings of 4.3 counts compared to the baseline wing-body configuration (approximately 5% of total drag). Off-design evaluations at near-cruise and low-speed, high-lift conditions are discussed, as well as attachment line contamination/transition concerns. This computational NLF design effort is a part of an ongoing cooperative agreement between NASA and JAXA researchers.

Lynde, Michelle N.↗